D81
Non-billableCombined immunodeficiencies
Combined immunodeficiencies
This is a header/category code. For billing purposes, use a more specific child code from the list below.
Coding Notes
Includes
Conditions included under this code
- defects in the complement system
- immunodeficiency disorders, except human immunodeficiency virus [HIV] disease
- sarcoidosis
Excludes 1
Codes that cannot be used together with this code (mutual exclusion)
Excludes 2
Conditions not included here, but the patient may have both
- •autoimmune disease (systemic) NOSM35.9
- •certain conditions originating in the perinatal periodP00-P96
- •complications of pregnancy, childbirth and the puerperiumO9A)O00
- •congenital malformations, deformations and chromosomal abnormalitiesQ00-Q99
- •endocrine, nutritional and metabolic diseasesE00-E88
- •human immunodeficiency virus [HIV] diseaseB20
- •injury, poisoning and certain other consequences of external causesS00-T88
- •neoplasmsC00-D49
- •symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classifiedR00-R94
Child Codes (10)
D81.0Severe combined immunodeficiency with reticular dysgenesis
D81.1Severe combined immunodeficiency w low T- and B-cell numbers
D81.2Severe combined immunodef w low or normal B-cell numbers
D81.3Adenosine deaminase [ADA] deficiency
D81.4Nezelof's syndrome
D81.5Purine nucleoside phosphorylase [PNP] deficiency
D81.6Major histocompatibility complex class I deficiency
D81.7Major histocompatibility complex class II deficiency
D81.8Other combined immunodeficiencies
D81.9Combined immunodeficiency, unspecified
ICD-11 Equivalents(1)
ICD-11 Equivalents
View full mappingCorresponding ICD-11 codes from the WHO crosswalk mapping
Also Known As / Clinical Terms(11)
UMLS
- Combined immunity deficiencyC2711630
- Combined immunodeficienciesC2711630
- Combined immunodeficiencyC2711630
- Combined immunodeficiency diseaseC2711630
- Combined immunodeficiency disease (disorder)C2711630
- Combined immunodeficiency syndromeC2711630
- Combined immunodeficiency, unspecifiedC2711630
- Congenital Combined ImmunodeficiencyC2711630
- combined immunity deficiencyC2711630
- combined immunodeficiencyC2711630
- combined immunodeficiency syndromeC2711630
Frequently Asked Questions
What is the ICD-10 code for combined immunodeficiencies?
The ICD-10-CM code for combined immunodeficiencies is D81. The full clinical description is "Combined immunodeficiencies". D81 is a non-billable header code. Use a more specific child code for billing purposes.
What does ICD-10 code D81 mean?
ICD-10-CM code D81 represents “Combined immunodeficiencies”. It is classified under Chapter 3: Diseases of the Blood and Blood-Forming Organs and is a non-billable header code. Use a more specific child code for billing purposes.
Is D81 a billable code?
No, D81 is a non-billable header code. You need to use one of its more specific child codes for billing. There are 10 child codes under D81.
What chapter is D81 in?
D81 is in Chapter 3: Diseases of the Blood and Blood-Forming Organs (codes D50-D89).
What codes cannot be used with D81?
D81 has Excludes1 notes indicating codes that cannot be used together with it, including: autoimmune disease (systemic) NOS (M35.9); functional disorders of polymorphonuclear neutrophils (D71); human immunodeficiency virus [HIV] disease (B20); and 1 more.
What are the subcategories under D81?
D81 has 10 child codes, including: D81.0 (Severe combined immunodeficiency with reticular dysgenesis), D81.1 (Severe combined immunodeficiency w low T- and B-cell numbers), D81.2 (Severe combined immunodef w low or normal B-cell numbers), D81.3 (Adenosine deaminase [ADA] deficiency), and 6 more.
What are the UMLS CUIs for D81?
D81 is linked to 1 UMLS Concept Unique Identifier: C2711630. The UMLS (Unified Medical Language System) integrates multiple biomedical vocabularies maintained by the U.S. National Library of Medicine.
How does D81 relate to ICF functioning codes?
ICF (International Classification of Functioning, Disability and Health) codes describe how conditions like combined immunodeficiencies affect a person's functioning — body functions, activities, participation, and environmental factors. AutoICD provides ICF Core Sets for 12+ conditions and can map clinical text to ICF categories automatically. Browse the ICF directory to explore functioning codes.
What is the ICD-11 equivalent of D81?
D81 maps to the ICD-11 code: 4A01.1Z (Combined immunodeficiencies, unspecified).
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Includes SNOMED Clinical Terms® (SNOMED CT®) used by permission of SNOMED International. Includes content from the UMLS Metathesaurus, courtesy of the U.S. National Library of Medicine.