D89.83
Non-billableCytokine release syndrome
Cytokine release syndrome
This is a header/category code. For billing purposes, use a more specific child code from the list below.
Coding Notes
Includes
Conditions included under this code
- defects in the complement system
- immunodeficiency disorders, except human immunodeficiency virus [HIV] disease
- sarcoidosis
Excludes 1
Codes that cannot be used together with this code (mutual exclusion)
Excludes 2
Conditions not included here, but the patient may have both
- •autoimmune disease (systemic) NOSM35.9
- •certain conditions originating in the perinatal periodP00-P96
- •complications of pregnancy, childbirth and the puerperiumO9A)O00
- •congenital malformations, deformations and chromosomal abnormalitiesQ00-Q99
- •endocrine, nutritional and metabolic diseasesE00-E88
- •human immunodeficiency virus [HIV] diseaseB20
- •injury, poisoning and certain other consequences of external causesS00-T88
- •neoplasmsC00-D49
- •symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classifiedR00-R94
- •transplant failure and rejectionT86
Code First
The underlying condition must be sequenced before this code
Use Additional Code
Additional codes that should follow this code
Child Codes (6)
D89.831Cytokine release syndrome, grade 1
D89.832Cytokine release syndrome, grade 2
D89.833Cytokine release syndrome, grade 3
D89.834Cytokine release syndrome, grade 4
D89.835Cytokine release syndrome, grade 5
D89.839Cytokine release syndrome, grade unspecified
Related Codes(4)
Also Known As / Clinical Terms(9)
UMLS
- CRS - cytokine release syndromeC0948245
- Cytokine Release SyndromeC0948245
- Cytokine Release SyndromesC0948245
- Cytokine Storm SyndromeC0948245
- Cytokine release syndromeC0948245
- Cytokine-associated toxicityC0948245
- Cytokine-associated toxicity (disorder)C0948245
- HypercytokinemiaC0948245
- HypercytokinemiasC0948245
Frequently Asked Questions
What is the ICD-10 code for cytokine release syndrome?
The ICD-10-CM code for cytokine release syndrome is D89.83. The full clinical description is "Cytokine release syndrome". D89.83 is a non-billable header code. Use a more specific child code for billing purposes.
What does ICD-10 code D89.83 mean?
ICD-10-CM code D89.83 represents “Cytokine release syndrome”. It is classified under Chapter 3: Diseases of the Blood and Blood-Forming Organs and is a non-billable header code. Use a more specific child code for billing purposes.
Is D89.83 a billable code?
No, D89.83 is a non-billable header code. You need to use one of its more specific child codes for billing. There are 6 child codes under D89.83.
What chapter is D89.83 in?
D89.83 is in Chapter 3: Diseases of the Blood and Blood-Forming Organs (codes D50-D89).
What codes cannot be used with D89.83?
D89.83 has Excludes1 notes indicating codes that cannot be used together with it, including: autoimmune disease (systemic) NOS (M35.9); functional disorders of polymorphonuclear neutrophils (D71); human immunodeficiency virus [HIV] disease (B20); and 2 more.
What are the subcategories under D89.83?
D89.83 has 6 child codes, including: D89.831 (Cytokine release syndrome, grade 1), D89.832 (Cytokine release syndrome, grade 2), D89.833 (Cytokine release syndrome, grade 3), D89.834 (Cytokine release syndrome, grade 4), and 2 more.
Are additional codes required with D89.83?
Yes, when using D89.83, also report: adverse effect, if applicable, to identify immune checkpoint inhibitors and immunostimulant drugs (T45.AX5).
What are the UMLS CUIs for D89.83?
D89.83 is linked to 1 UMLS Concept Unique Identifier: C0948245. The UMLS (Unified Medical Language System) integrates multiple biomedical vocabularies maintained by the U.S. National Library of Medicine.
How does D89.83 relate to ICF functioning codes?
ICF (International Classification of Functioning, Disability and Health) codes describe how conditions like cytokine release syndrome affect a person's functioning — body functions, activities, participation, and environmental factors. AutoICD provides ICF Core Sets for 12+ conditions and can map clinical text to ICF categories automatically. Browse the ICF directory to explore functioning codes.
What is the ICD-11 equivalent of D89.83?
There is no direct ICD-11 mapping available for D89.83 in the WHO crosswalk tables. This may mean the concept is classified differently in ICD-11. Use the ICD-10 to ICD-11 converter to search for related codes.
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Includes SNOMED Clinical Terms® (SNOMED CT®) used by permission of SNOMED International. Includes content from the UMLS Metathesaurus, courtesy of the U.S. National Library of Medicine.