E88.4
Non-billableMitochondrial metabolism disorders
Mitochondrial metabolism disorders
This is a header/category code. For billing purposes, use a more specific child code from the list below.
Coding Notes
Excludes 1
Codes that cannot be used together with this code (mutual exclusion)
- transitory endocrine and metabolic disorders specific to newborn (P70-P74)
- androgen insensitivity syndrome (E34.5-)
- congenital adrenal hyperplasia (E25.0)
- hemolytic anemias attributable to enzyme disorders (D55.-)
- Marfan syndrome (Q87.4-)
- 5-alpha-reductase deficiency (E29.1)
- histiocytosis X (chronic) (C96.6)
- disorders of pyruvate metabolism (E74.4)
- Kearns-Sayre syndrome (H49.81)
- Leber's disease (H47.22)
- Leigh's encephalopathy (G31.82)
- Mitochondrial myopathy, NEC (G71.3)
- Reye's syndrome (G93.7)
Excludes 2
Conditions not included here, but the patient may have both
- Ehlers-Danlos syndromes (Q79.6-)
Use Additional Code
Additional codes that should follow this code
- codes for associated conditions
Child Codes (5)
Also Known As / Clinical Terms
Frequently Asked Questions
What is ICD-10 code E88.4?
ICD-10-CM code E88.4 represents "Mitochondrial metabolism disorders". It is a non-billable header code — use a more specific child code for billing purposes.
Is E88.4 a billable code?
No, E88.4 is a non-billable header code. You need to use one of its more specific child codes for billing. There are 5 child codes under E88.4.
What chapter is E88.4 in?
E88.4 is in Chapter 4: Endocrine, Nutritional and Metabolic Diseases (codes E00-E89).
What codes cannot be used with E88.4?
E88.4 has Excludes1 notes indicating codes that cannot be used together with it, including: transitory endocrine and metabolic disorders specific to newborn (P70-P74); androgen insensitivity syndrome (E34.5-); congenital adrenal hyperplasia (E25.0); and 10 more.
What are the subcategories under E88.4?
E88.4 has 5 child codes, including: E88.40 (Mitochondrial metabolism disorder, unspecified), E88.41 (MELAS syndrome), E88.42 (MERRF syndrome), E88.43 (Disorders of mitochondrial tRNA synthetases), and 1 more.
Are additional codes required with E88.4?
Yes, when using E88.4 you should also code: codes for associated conditions.
What are the UMLS CUIs for E88.4?
E88.4 is linked to 1 UMLS Concept Unique Identifier: C1456275. The UMLS (Unified Medical Language System) integrates multiple biomedical vocabularies maintained by the U.S. National Library of Medicine.
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Includes SNOMED Clinical Terms® (SNOMED CT®) used by permission of SNOMED International. Includes content from the UMLS Metathesaurus, courtesy of the U.S. National Library of Medicine.