99971-4
LaboratoryHemophagocytic lymphohistiocytosis multigene analysis in Blood or Tissue by Molecular genetics method
Definition
Multigene analysis for hemophagocytic lymphohistiocytosis (HLH), a syndrome characterized by hyperactivation of the immune system, excessive cytokine secretion and severe systemic inflammation. HLH is classified as familial (FHL) when associated with mutations in specific genes, such as PRF1, UNC13D, STX11, and STXBP2 genes.[PMID: 33746956] Testing is performed for diagnostic, prognostic, and therapeutic assessment in patients with HLH.
LOINC 6-Axis Classification
Component
Hemophagocytic lymphohistiocytosis multigene analysis
Property
Find
Time Aspect
Pt
System
Bld/Tiss
Scale Type
Doc
Method Type
Molgen
Details
Class
MOLPATH
Order/Observation
Both
Short Name
HLH multigene analysis Bld/T
Display Name
Hemophagocytic lymphohistiocytosis multigene analysis Molgen Doc (Bld/Tiss)
Related Names
Frequently Asked Questions
What is LOINC code 99971-4?
LOINC code 99971-4 identifies "Hemophagocytic lymphohistiocytosis multigene analysis in Blood or Tissue by Molecular genetics method". Multigene analysis for hemophagocytic lymphohistiocytosis (HLH), a syndrome characterized by hyperactivation of the immune system, excessive cytokine secretion and severe systemic inflammation. HLH is classified as familial (FHL) when associated with mutations in specific genes, such as PRF1, UNC13D, STX11, and STXBP2 genes.[PMID: 33746956] Testing is performed for diagnostic, prognostic, and therapeutic assessment in patients with HLH.
What does 99971-4 measure?
This code measures Hemophagocytic lymphohistiocytosis multigene analysis in Bld/Tiss. It belongs to the MOLPATH class in the LOINC classification.
What is LOINC?
LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.