98122-5
LaboratoryNeutrophil.fMLP and PMA stimulated DHR panel by Flow cytometry (FC)
Definition
The phorbol myristate acetate (PMA) and N-formyl-methionyl-leucyl-phenylalanine (fMLP) stimulated neutrophil dihydrorhodamine (DHR) test assesses neutrophil activation and NADPH oxidase function when stimulated by PMA and fMLP (different populations of neutrophils are stimulated by PMA and fMLP, respectively). This test is used to diagnose chronic granulomatous disease (CGD) and complete myeloperoxidase deficiency; monitor chimerism and NADPH oxidase function after stem cell transplant, assess NADPH oxidase activity prior to transplant; identify and monitor chromosome X inactivation changes with age in carrier females with X-linked CGD; and diagnose Rac2 deficiency. To report results for the fMLP stimulated neutrophil DHR test alone, use [LOINC: 98123-3]. To report results for the PMA stimulated neutrophil DHR test alone, use [LOINC: 98124-1].
LOINC 6-Axis Classification
Component
Neutrophil.fMLP & PMA stimulated DHR panel
Property
-
Time Aspect
Pt
System
^Patient
Scale Type
-
Method Type
Flow cytometry
Details
Class
PANEL.HEM/BC
Order/Observation
Order
Short Name
Neut fMLP + PMA stim DHR Pnl Patient FC
Display Name
Neutrophil.fMLP and PMA stimulated DHR panel FC
Related Names
Frequently Asked Questions
What is LOINC code 98122-5?
LOINC code 98122-5 identifies "Neutrophil.fMLP and PMA stimulated DHR panel by Flow cytometry (FC)". The phorbol myristate acetate (PMA) and N-formyl-methionyl-leucyl-phenylalanine (fMLP) stimulated neutrophil dihydrorhodamine (DHR) test assesses neutrophil activation and NADPH oxidase function when stimulated by PMA and fMLP (different populations of neutrophils are stimulated by PMA and fMLP, respectively). This test is used to diagnose chronic granulomatous disease (CGD) and complete myeloperoxidase deficiency; monitor chimerism and NADPH oxidase function after stem cell transplant, assess NADPH oxidase activity prior to transplant; identify and monitor chromosome X inactivation changes with age in carrier females with X-linked CGD; and diagnose Rac2 deficiency. To report results for the fMLP stimulated neutrophil DHR test alone, use [LOINC: 98123-3]. To report results for the PMA stimulated neutrophil DHR test alone, use [LOINC: 98124-1].
What does 98122-5 measure?
This code measures Neutrophil.fMLP & PMA stimulated DHR panel in ^Patient. It belongs to the PANEL.HEM/BC class in the LOINC classification.
What is LOINC?
LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.