97656-3

LOINC code 97656-3 identifies "Hereditary cancer multigene analysis in Blood or Tissue by Molecular genetics method". Multigene testing for heritable germline mutations in genes associated with cancer in various organ systems, including breast and gynecologic (breast, ovarian, uterine), gastrointestinal (colorectal, gastric, pancreatic), endocrine (thyroid, paraganglioma/pheochromocytoma, parathyroid, pituitary), genitourinary (renal/urinary tract, prostate), skin (melanoma, basal cell carcinoma), brain/nervous system, and bone/soft tissue (sarcoma) & blood (myelodysplastic syndrome/leukemia). Testing is performed to confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variants may also used to inform at-risk relatives. Approximately 5-10 percent of cancers are thought to be hereditary.[PMID: 15637391] This test is not appropriate for the detection of somatic mutations in tumor tissue since it is focused on heritable germline mutations.

This code measures Hereditary cancer multigene analysis in Bld/Tiss. It belongs to the MOLPATH class in the LOINC classification.

LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.