97503-7
LaboratoryAbnormal Prion Protein [Presence] in Cerebral spinal fluid
Definition
Detection of pathologic prions in cerebrospinal fluid (CSF). The submitter's test uses recombinant prion protein (PrP) as a reagent substrate and patient CSF in a real-time quaking-induced conversion (RT-QuIC) assay. If pathologic prions are present in the patient's CSF, they propagate misfolding of the reagent PrP to form amyloid, which is detected using a fluorescent indicator. RT-QuIC has been adopted in clinical practice due to the sensitivity, specificity, and use of CSF (not a brain biopsy) for testing. The submitter's reported sensitivity of RT-QuIC in detecting CJD is >90%, and the specificity approaches 100%.
LOINC 6-Axis Classification
Component
Prion protein.abnormal
Property
PrThr
Time Aspect
Pt
System
CSF
Scale Type
Ord
Method Type
N/A
Details
Class
MICRO
Order/Observation
Both
Short Name
Abn Prion Prot CSF Ql
Display Name
Abnormal Prion Protein Ql (CSF)
Related Names
Frequently Asked Questions
What is LOINC code 97503-7?
LOINC code 97503-7 identifies "Abnormal Prion Protein [Presence] in Cerebral spinal fluid". Detection of pathologic prions in cerebrospinal fluid (CSF). The submitter's test uses recombinant prion protein (PrP) as a reagent substrate and patient CSF in a real-time quaking-induced conversion (RT-QuIC) assay. If pathologic prions are present in the patient's CSF, they propagate misfolding of the reagent PrP to form amyloid, which is detected using a fluorescent indicator. RT-QuIC has been adopted in clinical practice due to the sensitivity, specificity, and use of CSF (not a brain biopsy) for testing. The submitter's reported sensitivity of RT-QuIC in detecting CJD is >90%, and the specificity approaches 100%.
What does 97503-7 measure?
This code measures Prion protein.abnormal in CSF. It belongs to the MICRO class in the LOINC classification.
What is LOINC?
LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.