96463-5

LOINC code 96463-5 identifies "Copper free/Total copper in Serum or Plasma by calculation". A free copper level is calculated based on the difference between total copper and ceruloplasmin measurements, where the ceruloplasmin level represents the bound portion of circulating copper. In patients with Wilson's disease that is pre-symptomatic or adequately controlled, the free copper level is within normal range, but in symptomatic patients, it is typically elevated. Increasing free copper levels in a patient with previously normal levels may indicate a change in compliance with therapy or a growth spurt or change in diet requiring therapy adjustment. [PMID: 12662398] This term represents the calculated result for free copper level as a fraction of the total copper measurement.

This code measures Copper.free/Copper.total in Ser/Plas. It belongs to the DRUG/TOX class in the LOINC classification.

LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.