95143-4
LaboratoryUGT1A1 gene TA repeats [Genotype] in Blood or Tissue by Molecular genetics method Nominal
Definition
The patient's genotype (e.g. TA5/TA7) for the TA repeat variant within the UGT1A1 gene. Variants include TA5 or *36: c.−41_-40delTA (g.234668893_234668894), TA7 or *28: c.−41_-40dupTA (g.234668893_234668894), and TA8 or *37: c.−43_-40dupTATA (g. 234668891_234668894). Testing is performed to screen for variants associated with increased risk of adverse drug reactions when taking UGT1A1-metabolized drugs, including pazopanib, nilotinib, atazanavir, and belinostat. Patient's homozygosity for the TA7 promoter variant (*28) have reduced UGT1A1 activity (about 30% to 50%) compared to normal.[PMID: 7565971]
LOINC 6-Axis Classification
Component
UGT1A1 gene.TA repeats
Property
Geno
Time Aspect
Pt
System
Bld/Tiss
Scale Type
Nom
Method Type
Molgen
Details
Class
MOLPATH.PHARMG
Order/Observation
Both
Short Name
UGT1A1 TA Geno Bld/T
Display Name
UGT1A1 gene TA repeats genotype Molgen (Bld/Tiss)
Related Names
Frequently Asked Questions
What is LOINC code 95143-4?
LOINC code 95143-4 identifies "UGT1A1 gene TA repeats [Genotype] in Blood or Tissue by Molecular genetics method Nominal". The patient's genotype (e.g. TA5/TA7) for the TA repeat variant within the UGT1A1 gene. Variants include TA5 or *36: c.−41_-40delTA (g.234668893_234668894), TA7 or *28: c.−41_-40dupTA (g.234668893_234668894), and TA8 or *37: c.−43_-40dupTATA (g. 234668891_234668894). Testing is performed to screen for variants associated with increased risk of adverse drug reactions when taking UGT1A1-metabolized drugs, including pazopanib, nilotinib, atazanavir, and belinostat. Patient's homozygosity for the TA7 promoter variant (*28) have reduced UGT1A1 activity (about 30% to 50%) compared to normal.[PMID: 7565971]
What does 95143-4 measure?
This code measures UGT1A1 gene.TA repeats in Bld/Tiss. It belongs to the MOLPATH.PHARMG class in the LOINC classification.
What is LOINC?
LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.