94076-7
LaboratoryMutations/Megabase [# Ratio] in Tumor
Definition
Tumor mutation/mutational burden (TMB), also known as mutation load, is a biomarker for various cancer types to identify patients who will benefit from immunotherapy, such as immune checkpoint blockade (ICB) therapy.[PMID: 30395155] Various quantitative and ordinal results may be reported, so it is important to distinguish the type of results when mapping to LOINC. Quantitative results typically include the number of mutations detected per megabase (mut/Mb), often by NGS, in a tumor specimen (this term). The mutations targeted may include non-synonymous or both synonymous and non-synonymous mutations. An ordinal TMB result [LOINC: 94077-5] of high, low, etc., may also be reported to provide an overall interpretation for the quantitative value (muts/Mb). We encourage labs to report how results are determined or calculated in either the structured message format or using another LOINC.
LOINC 6-Axis Classification
Component
Mutations/Megabase
Property
NRto
Time Aspect
Pt
System
Tumor
Scale Type
Qn
Method Type
N/A
Details
Class
MOLPATH.MUT
Order/Observation
Observation
Short Name
Muts/Mb Tumor
Display Name
Mutations/Megabase (Tumor) [# ratio]
Related Names
Frequently Asked Questions
What is LOINC code 94076-7?
LOINC code 94076-7 identifies "Mutations/Megabase [# Ratio] in Tumor". Tumor mutation/mutational burden (TMB), also known as mutation load, is a biomarker for various cancer types to identify patients who will benefit from immunotherapy, such as immune checkpoint blockade (ICB) therapy.[PMID: 30395155] Various quantitative and ordinal results may be reported, so it is important to distinguish the type of results when mapping to LOINC. Quantitative results typically include the number of mutations detected per megabase (mut/Mb), often by NGS, in a tumor specimen (this term). The mutations targeted may include non-synonymous or both synonymous and non-synonymous mutations. An ordinal TMB result [LOINC: 94077-5] of high, low, etc., may also be reported to provide an overall interpretation for the quantitative value (muts/Mb). We encourage labs to report how results are determined or calculated in either the structured message format or using another LOINC.
What does 94076-7 measure?
This code measures Mutations/Megabase in Tumor. It belongs to the MOLPATH.MUT class in the LOINC classification.
What is LOINC?
LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.