90919-2
LaboratoryCoagulation factor VIII.recombinant.bound/von Willebrand factor (vWf) Ag in Plasma by Immunoassay
Definition
This test measures the binding activity of von Willebrand factor (vWF) to Factor VIII as the ratio of the amount of exogenous recombinant Factor VIII bound to vWF in the patient sample to the amount of vWF in the patient sample. It is used to differentiate between various bleeding disorders including hemophilia A and type 2N von Willebrand disease (2N vWD, VWD2N, or Type 2 Normandy). Type 2N vWD is caused by mutations to the Factor VIII binding site of vWF, which results in reduced binding and faster clearance of Factor VIII. Patients with type 2N vWD usually have reduced Factor VIII activity with normal VWF levels. [PMID: 19298374]
LOINC 6-Axis Classification
Component
Coagulation factor VIII.recombinant.bound/von Willebrand factor Ag
Property
RelRto
Time Aspect
Pt
System
Plas
Scale Type
Qn
Method Type
IA
Details
Class
COAG
Order/Observation
Both
Short Name
Fact VIII.recomb.bound/vWF Ag Plas IA
Display Name
Bound rFVIII/vWf Ag IA (P) [Relative ratio]
Related Names
Frequently Asked Questions
What is LOINC code 90919-2?
LOINC code 90919-2 identifies "Coagulation factor VIII.recombinant.bound/von Willebrand factor (vWf) Ag in Plasma by Immunoassay". This test measures the binding activity of von Willebrand factor (vWF) to Factor VIII as the ratio of the amount of exogenous recombinant Factor VIII bound to vWF in the patient sample to the amount of vWF in the patient sample. It is used to differentiate between various bleeding disorders including hemophilia A and type 2N von Willebrand disease (2N vWD, VWD2N, or Type 2 Normandy). Type 2N vWD is caused by mutations to the Factor VIII binding site of vWF, which results in reduced binding and faster clearance of Factor VIII. Patients with type 2N vWD usually have reduced Factor VIII activity with normal VWF levels. [PMID: 19298374]
What does 90919-2 measure?
This code measures Coagulation factor VIII.recombinant.bound/von Willebrand factor Ag in Plas. It belongs to the COAG class in the LOINC classification.
What is LOINC?
LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.