90735-2
LaboratoryPNH GPI-Linked WBC and RBC Ag Panel - Blood
Definition
The tests in this panel detect glycosylphosphatidylinositol (GPI)-linked proteins including CD14 for monocytes, CD16 and 24 for granulocytes, and CD59 for erythrocytes. In addition, fluorescent aerolysin (FLAER) which selectively binds to GPI anchor proteins, is also used to detect the presence or absence of those anchors. Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hematologic disorder of erythroid, granulocytic, and megakaryocytic cell lines. The abnormal cells in PNH are missing the GPI-linked proteins due to mutations in the phosphatidylinositol glycan A gene (PIGA).
LOINC 6-Axis Classification
Component
Paroxysmal nocturnal hemoglobinuria GPI-Linked WBC & RBC Ag Panel
Property
-
Time Aspect
Pt
System
Bld
Scale Type
-
Method Type
N/A
Details
Class
PANEL.CELLMARK
Order/Observation
Order
Short Name
PNH GPI-Lkd WBC + RBC Ag Pnl Bld
Display Name
PNH GPI-Linked WBC and RBC Ag Panel (Bld)
Related Names
Frequently Asked Questions
What is LOINC code 90735-2?
LOINC code 90735-2 identifies "PNH GPI-Linked WBC and RBC Ag Panel - Blood". The tests in this panel detect glycosylphosphatidylinositol (GPI)-linked proteins including CD14 for monocytes, CD16 and 24 for granulocytes, and CD59 for erythrocytes. In addition, fluorescent aerolysin (FLAER) which selectively binds to GPI anchor proteins, is also used to detect the presence or absence of those anchors. Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hematologic disorder of erythroid, granulocytic, and megakaryocytic cell lines. The abnormal cells in PNH are missing the GPI-linked proteins due to mutations in the phosphatidylinositol glycan A gene (PIGA).
What does 90735-2 measure?
This code measures Paroxysmal nocturnal hemoglobinuria GPI-Linked WBC & RBC Ag Panel in Bld. It belongs to the PANEL.CELLMARK class in the LOINC classification.
What is LOINC?
LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.