88460-1
LaboratorySerotonin release 50 IU/mL heparin.low molecular weight [Units/volume] in Serum
Definition
The SRA test is a functional assay that measures heparin-dependent platelet activation. Patient serum is incubated with donor platelets containing radioactive 14C serotonin and different concentrations of heparin. Antibody present in the patient serum will bind and activate donor platelets, releasing radiolabeled serotonin from the platelet granules. A positive SRA is expected to show >20% release of the 14C serotonin when mixed with patient serum and low-dose heparin. In addition, the high-dose heparin must reduce the % release obtained with low-dose heparin by at least 50% in order to demonstrate that the platelet activation is heparin dependent.
LOINC 6-Axis Classification
Component
Serotonin release 50 IU/mL heparin.low molecular weight
Property
ACnc
Time Aspect
Pt
System
Ser
Scale Type
Qn
Method Type
N/A
Details
Class
SERO
Order/Observation
Both
Short Name
SRA 50 IU/mL LMW heparin Ser-aCnc
Display Name
Serotonin release 50 IU/mL heparin.low molecular weight Qn (S)
Related Names
Frequently Asked Questions
What is LOINC code 88460-1?
LOINC code 88460-1 identifies "Serotonin release 50 IU/mL heparin.low molecular weight [Units/volume] in Serum". The SRA test is a functional assay that measures heparin-dependent platelet activation. Patient serum is incubated with donor platelets containing radioactive 14C serotonin and different concentrations of heparin. Antibody present in the patient serum will bind and activate donor platelets, releasing radiolabeled serotonin from the platelet granules. A positive SRA is expected to show >20% release of the 14C serotonin when mixed with patient serum and low-dose heparin. In addition, the high-dose heparin must reduce the % release obtained with low-dose heparin by at least 50% in order to demonstrate that the platelet activation is heparin dependent.
What does 88460-1 measure?
This code measures Serotonin release 50 IU/mL heparin.low molecular weight in Ser. It belongs to the SERO class in the LOINC classification.
What is LOINC?
LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.