82937-4
LaboratorySAP and XIAP [Interpretation] in Leukocytes by Flow cytometry (FC)
Definition
Analysis of SLAM (signaling lymphocytic activation molecule)-associated protein (SAP) and X-linked inhibitor of apoptosis protein (XIAP) levels by flow cytometry is performed as a preliminary screen for X-linked lymphoproliferative (XLP) disease and X-linked familial hemophagocytic lymphohistiocytosis (HLH). If SAP protein levels are absent or decreased, XLP is suspected. If XIAP protein levels are absent or decreased, HLH (aka XLP-2) is suspected. The diagnosis is confirmed by genetic analysis of the associated genes (SH2D1A gene for XLP, BIRC4 gene for HLH).
LOINC 6-Axis Classification
Component
Signaling lymphocytic activation molecule (SLAM)-associated & X-linked inhibitor of apoptosis protein
Property
Imp
Time Aspect
Pt
System
WBC
Scale Type
Nom
Method Type
Flow cytometry
Details
Class
CHEM
Order/Observation
Both
Short Name
SAP + XIAP WBC FC-Imp
Display Name
SAP and XIAP FC (WBC) [Interp]
Related Names
Frequently Asked Questions
What is LOINC code 82937-4?
LOINC code 82937-4 identifies "SAP and XIAP [Interpretation] in Leukocytes by Flow cytometry (FC)". Analysis of SLAM (signaling lymphocytic activation molecule)-associated protein (SAP) and X-linked inhibitor of apoptosis protein (XIAP) levels by flow cytometry is performed as a preliminary screen for X-linked lymphoproliferative (XLP) disease and X-linked familial hemophagocytic lymphohistiocytosis (HLH). If SAP protein levels are absent or decreased, XLP is suspected. If XIAP protein levels are absent or decreased, HLH (aka XLP-2) is suspected. The diagnosis is confirmed by genetic analysis of the associated genes (SH2D1A gene for XLP, BIRC4 gene for HLH).
What does 82937-4 measure?
This code measures Signaling lymphocytic activation molecule (SLAM)-associated & X-linked inhibitor of apoptosis protein in WBC. It belongs to the CHEM class in the LOINC classification.
What is LOINC?
LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.