AutoICD API

81879-9

Laboratory

t(11;22)(q24;q12.2)(FLI1,EWSR1) and t(21;22)(q22.3;q12.2)(ERG,EWSR1) fusion transcript in Blood or Tissue by Molecular genetics method

Definition

Rearrangements of the EWSR1 gene at 22q12 with FLI1 at 11q24 or ERG at 21q22 collectively occur in about 95% of Ewing sarcoma (EWS) and primitive neuroectodermal tumors (PNET), both types of small round-cell tumors. The fusion transcripts can be detected by various methods, including reverse transcriptase PCR and FISH. A positive result is consistent with a diagnosis of EWS/PNET. A negative result does not rule out the presence of fusion transcripts that may be present, but below the detection limit of an assay.

LOINC 6-Axis Classification

Component

t(11;22)(q24;q12.2)(FLI1,EWSR1) & t(21;22)(q22.3;q12.2)(ERG,EWSR1) fusion transcript

Property

Find

Time Aspect

Pt

System

Bld/Tiss

Scale Type

Doc

Method Type

Molgen

Details

Class

MOLPATH.TRNLOC

Order/Observation

Both

Short Name

EWSR1-FLI1 + EWSR1-ERG Bld/T

Display Name

t(11;22)(q24;q12.2)(FLI1,EWSR1) and t(21;22)(q22.3;q12.2)(ERG,EWSR1) fusion transcript Molgen Doc (Bld/Tiss)

Related Names

BloodDNADocumentEwing sarcoma breakpoint region 1Ewing sarcoma breakpoint region 2EWSEWSCREWSR1-FLI1 + EWSR1-ERGEWSR2FindingFindingsFriend leukemia virus integration 1gene fusiongene translocationGeneticsHeredityHeritableInheritedMolecular geneticsMolecular pathologyMOLPATHMOLPATH.TRANSLOCATIONPCRPoint in timeRandomRNASIC-1T primet(11,22)(FLI1,EWSR1) gene translocationt(1122)(FLI1,EWSR1)t(21,22)(ERG,EWSR1) gene translocationt(2122)(ERG,EWSR1)TissueTissue, unspecifiedtranslocationWBWhole bloodWhole blood or Tissue

Frequently Asked Questions

What is LOINC code 81879-9?

LOINC code 81879-9 identifies "t(11;22)(q24;q12.2)(FLI1,EWSR1) and t(21;22)(q22.3;q12.2)(ERG,EWSR1) fusion transcript in Blood or Tissue by Molecular genetics method". Rearrangements of the EWSR1 gene at 22q12 with FLI1 at 11q24 or ERG at 21q22 collectively occur in about 95% of Ewing sarcoma (EWS) and primitive neuroectodermal tumors (PNET), both types of small round-cell tumors. The fusion transcripts can be detected by various methods, including reverse transcriptase PCR and FISH. A positive result is consistent with a diagnosis of EWS/PNET. A negative result does not rule out the presence of fusion transcripts that may be present, but below the detection limit of an assay.

What does 81879-9 measure?

This code measures t(11;22)(q24;q12.2)(FLI1,EWSR1) & t(21;22)(q22.3;q12.2)(ERG,EWSR1) fusion transcript in Bld/Tiss. It belongs to the MOLPATH.TRNLOC class in the LOINC classification.

What is LOINC?

LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.