80618-2

LOINC code 80618-2 identifies "Zika virus IgM Ab [Units/volume] in Cerebral spinal fluid by Immunoassay". Quantitative analysis of Zika virus IgM antibodies in cerebral spinal fluid (CSF) specimens by immunoassay-based methods. Similar to most EIA tests, results are reported as a ratio of optical densities. Zika virus IgM antibodies become detectable 4-8 days after the onset of symptoms and persist for months. Since IgM does not normally cross the blood-brain barrier, detection of Zika virus IgM in CSF implies CNS infection. Serological cross-reactivity is strong between Zika and other flaviviruses, especially Dengue virus. Therefore, positive results for this test are presumptive and should be confirmed by neutralizing antibody testing [LOINC: 80621-6]. Negative results for this test on a sample taken during the first week of illness does not rule out infection and the test should be repeated on a convalescent sample.

This code measures Zika virus Ab.IgM in CSF. It belongs to the MICRO class in the LOINC classification.

LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.