78360-5
LaboratoryAcyl CoA dehydrogenases [Enzymatic activity/mass] in Fibroblast by [9,10-3H] myristate substrate
Definition
One method for diagnosing acyl CoA dehydrogenase deficiencies is fatty acid oxidation analysis in cultured fibroblasts. Using multiple fatty acid substrates with varying carbon chain lengths, such as palmitate (16 carbons) [LOINC: 78358-9] and and myristate (14 carbons) (this term), can help differentiate between disorders such as long-chain acyl CoA dehydrogenase deficiency and medium-chain acyl CoA dehydrogenase deficiency.[PMID: 2109149] Enzyme activity is measured as nanomoles of fatty acid oxidized per hour per milligram of cell protein (nmol FA/h/mg protein). [PMID: 12840153]
LOINC 6-Axis Classification
Component
Acyl CoA dehydrogenases
Property
CCnt
Time Aspect
Pt
System
Fibroblasts
Scale Type
Qn
Method Type
[9,10-3H] myristate substrate
Details
Class
CHEM
Order/Observation
Both
Short Name
ACADs Fib Myristate-cCnt
Display Name
Acyl CoA dehydrogenases [9,10-3H] myristate substrate (Fibroblast) [Catalytic activity/Mass]
Related Names
Frequently Asked Questions
What is LOINC code 78360-5?
LOINC code 78360-5 identifies "Acyl CoA dehydrogenases [Enzymatic activity/mass] in Fibroblast by [9,10-3H] myristate substrate". One method for diagnosing acyl CoA dehydrogenase deficiencies is fatty acid oxidation analysis in cultured fibroblasts. Using multiple fatty acid substrates with varying carbon chain lengths, such as palmitate (16 carbons) [LOINC: 78358-9] and and myristate (14 carbons) (this term), can help differentiate between disorders such as long-chain acyl CoA dehydrogenase deficiency and medium-chain acyl CoA dehydrogenase deficiency.[PMID: 2109149] Enzyme activity is measured as nanomoles of fatty acid oxidized per hour per milligram of cell protein (nmol FA/h/mg protein). [PMID: 12840153]
What does 78360-5 measure?
This code measures Acyl CoA dehydrogenases in Fibroblasts. It belongs to the CHEM class in the LOINC classification.
What is LOINC?
LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.