78359-7
LaboratoryAcyl CoA dehydrogenases.palmitate substrate/Acyl CoA dehydrogenases.myristate substrate [Enzymatic activity ratio] in Fibroblast
Definition
Medium- and long-chain acyl CoA dehydrogenase deficiencies can be differentiated based on the ratio of palmitate oxidation [LOINC: 78358-9] and myristate oxidation [LOINC: 78360-5] in cultured fibroblasts. Patients with medium chain acyl-CoA dehydrogenase deficiency (MCAD) typically have a high palmitate/myristate (P/M) ratio. Long-chain defects, including VLCAD and LCHAD, generally have a low P/M ratio. [PMID: 10709659]
LOINC 6-Axis Classification
Component
Acyl CoA dehydrogenases.palmitate substrate/Acyl CoA dehydrogenases.myristate substrate
Property
CRto
Time Aspect
Pt
System
Fibroblasts
Scale Type
Qn
Method Type
N/A
Details
Class
CHEM
Order/Observation
Observation
Short Name
ACADs.palmitate/ACADs.myristate Fib-cRto
Display Name
Acyl CoA dehydrogenases.palmitate substrate/Acyl CoA dehydrogenases.myristate substrate (Fibroblast) [Catalytic ratio]
Related Names
Frequently Asked Questions
What is LOINC code 78359-7?
LOINC code 78359-7 identifies "Acyl CoA dehydrogenases.palmitate substrate/Acyl CoA dehydrogenases.myristate substrate [Enzymatic activity ratio] in Fibroblast". Medium- and long-chain acyl CoA dehydrogenase deficiencies can be differentiated based on the ratio of palmitate oxidation [LOINC: 78358-9] and myristate oxidation [LOINC: 78360-5] in cultured fibroblasts. Patients with medium chain acyl-CoA dehydrogenase deficiency (MCAD) typically have a high palmitate/myristate (P/M) ratio. Long-chain defects, including VLCAD and LCHAD, generally have a low P/M ratio. [PMID: 10709659]
What does 78359-7 measure?
This code measures Acyl CoA dehydrogenases.palmitate substrate/Acyl CoA dehydrogenases.myristate substrate in Fibroblasts. It belongs to the CHEM class in the LOINC classification.
What is LOINC?
LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.