77349-9
LaboratoryEverolimus [Mass/volume] in Blood by LC/MS/MS --trough
Definition
Trough blood levels of everolimus is performed for therapeutic monitoring and dose individualization. Koster et. al. (2009) reported a systematic deviation in blood levels of everolimus (30% lower) measured by LC-MS/MS compared with immunoassays.[PMID: 19065123] Everolimus may be used to treat patients post transplant (e.g, kidney transplant) or with tuberous sclerosis complex (TSC) who have subependymal giant cell astrocytoma (SEGA). Maintaining everolimus troughs between 3-8 ng/mL is recommended for patients post transplant. Maintaining trough levels of 5 to 15 ng/mL is recommended in pediatric and adult patients with SEGA.
LOINC 6-Axis Classification
Component
Everolimus^trough
Property
MCnc
Time Aspect
Pt
System
Bld
Scale Type
Qn
Method Type
LC/MS/MS
Details
Class
DRUG/TOX
Order/Observation
Both
Short Name
Everolimus Trough Bld LC/MS/MS-mCnc
Display Name
Everolimus trough LC/MS/MS (Bld) [Mass/Vol]
Related Names
Frequently Asked Questions
What is LOINC code 77349-9?
LOINC code 77349-9 identifies "Everolimus [Mass/volume] in Blood by LC/MS/MS --trough". Trough blood levels of everolimus is performed for therapeutic monitoring and dose individualization. Koster et. al. (2009) reported a systematic deviation in blood levels of everolimus (30% lower) measured by LC-MS/MS compared with immunoassays.[PMID: 19065123] Everolimus may be used to treat patients post transplant (e.g, kidney transplant) or with tuberous sclerosis complex (TSC) who have subependymal giant cell astrocytoma (SEGA). Maintaining everolimus troughs between 3-8 ng/mL is recommended for patients post transplant. Maintaining trough levels of 5 to 15 ng/mL is recommended in pediatric and adult patients with SEGA.
What does 77349-9 measure?
This code measures Everolimus^trough in Bld. It belongs to the DRUG/TOX class in the LOINC classification.
What is LOINC?
LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.