77161-8

LOINC code 77161-8 identifies "Prothrombin activity [Units/volume] in Platelet poor plasma by Coagulation assay --immediately after addition of factor II depleted plasma". Tests for congenital or secondary deficiency of prothrombin (also called FII or factor II) by measuring prothrombin activity in patient plasma using a modified prothrombin time test (PT). Patient plasma is diluted and then added to a plasma deficient in prothrombin. Correction of the clotting time of the deficient plasma is proportional to the concentration (% activity) of that factor in the patient plasma, interpolated from a calibration curve. Prothrombin is a vitamin-K dependent plasma protein made in the liver and circulated in plasma. Congenital deficiency is very rare and usually causes minor bleeding. Secondary disorders are liver diseases, hyperfibrinolysis, disseminated intravascular coagulation (DIC), oral anticoagulant therapy, or vitamin-K deficiency. This term was created for, but not limited in use to, the HemolL Factor II deficient plasma test kit. Results may be expressed in % activity, IU/ml, or seconds.

This code measures Prothrombin.activity^immediately after addition of factor II depleted plasma in PPP. It belongs to the COAG class in the LOINC classification.

LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.