76545-3

LOINC code 76545-3 identifies "Breast cancer 10-year risk of distant recurrence classification [Interpretation] Qualitative by Prosigna". The risk classification is an ordinal risk category (low, intermediate, high) that indicates a patient's risk of recurrence of breast cancer at 10 years. The classification is based on the 10-year risk of distant recurrence score and lymph node status. Low risk is associated with a 3% chance (confidence interval 2-6%), intermediate risk is associated with a 10% chance (confidence interval 7-14%), and high risk with a 16% chance (confidence interval 11-22%) of distant breast cancer recurrence at 10 years, respectively. [PMID: 24347518] This term was created for the Prosigna™ Breast Cancer Prognostic Gene Signature assay, which is intended for use in postmenopausal women with node-negative (Stage I or II) or node-positive (Stage II), hormone receptor-positive (HR+) breast cancer who have undergone surgery and are to be treated with adjuvant endocrine therapy alone.

This code measures Breast cancer 10Y risk of distant recurrence classification in ^Patient. It belongs to the MOLPATH class in the LOINC classification.

LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.