76065-2
Laboratory6p25 and 6q23 and 11q and 8q24 and 9p21 chromosome partial aneuploidy in Blood or Tissue by FISH
Definition
Malignant melanoma often exhibits abnormal copy number of certain chromosomal regions. The assessment of gains and losses in 6p25, 6q23 11q, 8q24 and 9p21 by fluorescent in situ hybridization (FISH) has been found to be helpful in distinguishing benign from malignant melanocytic lesions. This term was created for the submitter's assay which uses three commercially available probes sets: RREB1/D6Z1/MYB/CCND1 (assessing chromosomes 6 and 11), CDKN2A/D9Z1 (assessing chromosome 9p), and D8Z2/MYC (assessing chromosome 8q). The chromosomal abnormalities in melanoma can be varied, so the combined assay has been found to have a better chance to aid in diagnosis. The findings have some mechanistic implications, with tumor suppressor genes on 9p and oncogene (MYC) on 8q.
LOINC 6-Axis Classification
Component
6p25 & 6q23 & 11q & 8q24 & 9p21 chromosome partial aneuploidy
Property
Find
Time Aspect
Pt
System
Bld/Tiss
Scale Type
Doc
Method Type
FISH
Details
Class
MOLPATH.MUT
Order/Observation
Both
Short Name
6p25+6q23+11q+8q24+9p21 aneup Bld/T FISH
Display Name
6p25 and 6q23 and 11q and 8q24 and 9p21 chromosome partial aneuploidy FISH Doc (Bld/Tiss)
Related Names
Frequently Asked Questions
What is LOINC code 76065-2?
LOINC code 76065-2 identifies "6p25 and 6q23 and 11q and 8q24 and 9p21 chromosome partial aneuploidy in Blood or Tissue by FISH". Malignant melanoma often exhibits abnormal copy number of certain chromosomal regions. The assessment of gains and losses in 6p25, 6q23 11q, 8q24 and 9p21 by fluorescent in situ hybridization (FISH) has been found to be helpful in distinguishing benign from malignant melanocytic lesions. This term was created for the submitter's assay which uses three commercially available probes sets: RREB1/D6Z1/MYB/CCND1 (assessing chromosomes 6 and 11), CDKN2A/D9Z1 (assessing chromosome 9p), and D8Z2/MYC (assessing chromosome 8q). The chromosomal abnormalities in melanoma can be varied, so the combined assay has been found to have a better chance to aid in diagnosis. The findings have some mechanistic implications, with tumor suppressor genes on 9p and oncogene (MYC) on 8q.
What does 76065-2 measure?
This code measures 6p25 & 6q23 & 11q & 8q24 & 9p21 chromosome partial aneuploidy in Bld/Tiss. It belongs to the MOLPATH.MUT class in the LOINC classification.
What is LOINC?
LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.