75708-8
LaboratoryBruton tyrosine kinase [Interpretation] in B cells+monocytes by Flow cytometry (FC) Narrative
Definition
Analysis of the Bruton tyrosine kinase (Btk) protein by flow cytometry is performed as a preliminary screen for X-linked agammaglobulinemia (XLA), primarily in male patients (<65 years of age) or female carriers (child-bearing age: <45 years). Since genotype-phenotype correlations are important, BTK gene sequencing [LOINC: 35295-5] is performed when the Btk protein is absent by flow cytometry to confirm the diagnosis of XLA.
LOINC 6-Axis Classification
Component
Bruton tyrosine kinase
Property
Imp
Time Aspect
Pt
System
B cells+monocytes
Scale Type
Nar
Method Type
Flow cytometry
Details
Class
CELLMARK
Order/Observation
Both
Short Name
Btk B cells+mono FC-Imp
Display Name
Bruton tyrosine kinase FC Nar (B cells+monocytes) [Interp]
Related Names
Frequently Asked Questions
What is LOINC code 75708-8?
LOINC code 75708-8 identifies "Bruton tyrosine kinase [Interpretation] in B cells+monocytes by Flow cytometry (FC) Narrative". Analysis of the Bruton tyrosine kinase (Btk) protein by flow cytometry is performed as a preliminary screen for X-linked agammaglobulinemia (XLA), primarily in male patients (<65 years of age) or female carriers (child-bearing age: <45 years). Since genotype-phenotype correlations are important, BTK gene sequencing [LOINC: 35295-5] is performed when the Btk protein is absent by flow cytometry to confirm the diagnosis of XLA.
What does 75708-8 measure?
This code measures Bruton tyrosine kinase in B cells+monocytes. It belongs to the CELLMARK class in the LOINC classification.
What is LOINC?
LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.