75515-7

LOINC code 75515-7 identifies "Lupus anticoagulant aPTT and dRVVT screening panel W Reflex". The development of this panel for detecting Lupus Anticoagulant (LA) was shaped by the 2009 International Society of Thrombosis and Haemostasis (ISTH) and 2014 Clinical and Laboratory Standards Institute (CLSI) guidelines for lupus anticoagulant testing. They both recommend using two separate coagulation tests and identify dRVVT and aPPT as the two best choices. This aPPT & dRVVT panel is most closely aligned with the ISTH guidelines. The testing cascade starts with the use of the two above-named tests to screen for or verify a clotting abnormality, and if either is abnormal, reflexing to the same test with 1:1 pooled plasma (to exclude clotting factor deficiencies) and again with excess phospholipid (PL). Correction of the coagulopathy with excess phospholipid confirms the likelihood of LA. Neither published guidance nor laboratories agree on the order in which the two kinds of reflex tests should be done, and this panel does not take a position on that subject. Some laboratories report the absolute values of the test and some the normalized ratios. So LOINC includes both as alternatives. Only one or the other of the alternatives must be included in the panel report. A summary interpretation is required by both guidelines.

This code measures Lupus anticoagulant two screening tests W Reflex panel in PPP. It belongs to the PANEL.COAG class in the LOINC classification.

LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.