74867-3
LaboratoryIgM.lambda [Mass/volume] in Serum or Plasma
Definition
Immunoglobulins are made up of two identical heavy chains which define the immunoglobulin class (A, G, or M) and two identical light chains, kappa or lambda (κ or λ). Each light chain is bound to a heavy chain. This test measures IgM, but selectively IgM with a lambda light chain. The assay employs antibodies that target unique junctional epitopes between the light and heavy chains for each Ig molecule. High serum concentrations of monoclonal protein may indicate an underlying abnormality such as multiple myeloma, monoclonal gammopathy of unknown significance (MGUS), or other lymphoproliferative disorders. [PMID:23211046] This term was based on, but not limited in use to, the Hevylite Human IgM Lambda assay.
LOINC 6-Axis Classification
Component
IgM.lambda
Property
MCnc
Time Aspect
Pt
System
Ser/Plas
Scale Type
Qn
Method Type
N/A
Details
Class
CHEM
Order/Observation
Both
Short Name
IgM lambda SerPl-mCnc
Display Name
IgM.lambda [Mass/Vol]
Related Names
Frequently Asked Questions
What is LOINC code 74867-3?
LOINC code 74867-3 identifies "IgM.lambda [Mass/volume] in Serum or Plasma". Immunoglobulins are made up of two identical heavy chains which define the immunoglobulin class (A, G, or M) and two identical light chains, kappa or lambda (κ or λ). Each light chain is bound to a heavy chain. This test measures IgM, but selectively IgM with a lambda light chain. The assay employs antibodies that target unique junctional epitopes between the light and heavy chains for each Ig molecule. High serum concentrations of monoclonal protein may indicate an underlying abnormality such as multiple myeloma, monoclonal gammopathy of unknown significance (MGUS), or other lymphoproliferative disorders. [PMID:23211046] This term was based on, but not limited in use to, the Hevylite Human IgM Lambda assay.
What does 74867-3 measure?
This code measures IgM.lambda in Ser/Plas. It belongs to the CHEM class in the LOINC classification.
What is LOINC?
LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.