74862-4

LOINC code 74862-4 identifies "IgG.kappa [Mass/volume] in Serum or Plasma". Immunoglobulins are made up of two identical heavy chains which define the immunoglobulin class (A, G, or M) and two identical light chains, kappa or lambda (κ or λ). Each light chain is bound to a heavy chain. This test measures IgG, but selectively IgG with a kappa light chain. The assay employs antibodies that target unique junctional epitopes between the light and heavy chains for each Ig molecule. High serum concentrations of monoclonal protein may indicate an underlying abnormality such as multiple myeloma, monoclonal gammopathy of unknown significance (MGUS), or other lymphoproliferative disorders. [PMID:23211046] This term was based on, but not limited in use to, the Hevylite Human IgG Kappa assay.

This code measures IgG.kappa in Ser/Plas. It belongs to the CHEM class in the LOINC classification.

LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.