72520-0
LaboratoryFLT3 gene.p.Asp835+Ile836 mutations [Presence] in Blood or Tissue by Molecular genetics method
Definition
Point mutations and deletions of codons D835 and I836 within the second tyrosine kinase domain (protein activation loop) of the FLT3 gene are detected by molecular genetic methods (e.g. PCR-based assays). This code was created for, but not limited to Invivoscribe's LeukoStrat(tm) FLT3 Gel Detection Mutation Assay, which detects the presence or absence of either D835 or I836 mutations within the second TKD but does not identify specific TKD mutations. FLT3-TKD mutations occur in approximately 7% of patients with acute myelogenous leukemia (AML).
LOINC 6-Axis Classification
Component
FLT3 gene.p.Asp835+Ile836 mutations
Property
PrThr
Time Aspect
Pt
System
Bld/Tiss
Scale Type
Ord
Method Type
Molgen
Details
Class
MOLPATH.MUT
Order/Observation
Both
Short Name
FLT3 p.D835+I836 Bld/T Ql
Display Name
FLT3 gene.p.Asp835+Ile836 mutations Molgen Ql (Bld/Tiss)
Related Names
Frequently Asked Questions
What is LOINC code 72520-0?
LOINC code 72520-0 identifies "FLT3 gene.p.Asp835+Ile836 mutations [Presence] in Blood or Tissue by Molecular genetics method". Point mutations and deletions of codons D835 and I836 within the second tyrosine kinase domain (protein activation loop) of the FLT3 gene are detected by molecular genetic methods (e.g. PCR-based assays). This code was created for, but not limited to Invivoscribe's LeukoStrat(tm) FLT3 Gel Detection Mutation Assay, which detects the presence or absence of either D835 or I836 mutations within the second TKD but does not identify specific TKD mutations. FLT3-TKD mutations occur in approximately 7% of patients with acute myelogenous leukemia (AML).
What does 72520-0 measure?
This code measures FLT3 gene.p.Asp835+Ile836 mutations in Bld/Tiss. It belongs to the MOLPATH.MUT class in the LOINC classification.
What is LOINC?
LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.