72503-6
LaboratoryWT1 gene exon 1+2 transcript/control transcript [# Ratio] in Blood or Tissue by Molecular genetics method
Definition
Wilm's tumor (WT1) gene expression is calculated by measuring the copy numbers of transcripts within exon 1 and 2 of the WTI gene compared to transcripts from a control gene. The WT1 gene expression is used as a specific molecular marker to improve diagnosis, prognosis and follow-up of adult acute myeloid leukemia (AML) patients. Early decreased expression of WT1 copy number in peripheral blood predicts better outcome for AML patients [PMID:20107153]. This code is based on, but not limited in use to, the submitter's package insert, Ipsogen's ProfileQuant® kit. This kit uses real-time quantitative PCR to quantify WT1 gene expression relative to ABL1 control gene.
LOINC 6-Axis Classification
Component
WT1 gene exon 1+2 transcript/control transcript
Property
NRto
Time Aspect
Pt
System
Bld/Tiss
Scale Type
Qn
Method Type
Molgen
Details
Class
MOLPATH.MUT
Order/Observation
Both
Short Name
WT1 ex 1+2/control Bld/T
Display Name
WT1 gene exon 1+2 transcript/control transcript Molgen (Bld/Tiss) [# ratio]
Related Names
Frequently Asked Questions
What is LOINC code 72503-6?
LOINC code 72503-6 identifies "WT1 gene exon 1+2 transcript/control transcript [# Ratio] in Blood or Tissue by Molecular genetics method". Wilm's tumor (WT1) gene expression is calculated by measuring the copy numbers of transcripts within exon 1 and 2 of the WTI gene compared to transcripts from a control gene. The WT1 gene expression is used as a specific molecular marker to improve diagnosis, prognosis and follow-up of adult acute myeloid leukemia (AML) patients. Early decreased expression of WT1 copy number in peripheral blood predicts better outcome for AML patients [PMID:20107153]. This code is based on, but not limited in use to, the submitter's package insert, Ipsogen's ProfileQuant® kit. This kit uses real-time quantitative PCR to quantify WT1 gene expression relative to ABL1 control gene.
What does 72503-6 measure?
This code measures WT1 gene exon 1+2 transcript/control transcript in Bld/Tiss. It belongs to the MOLPATH.MUT class in the LOINC classification.
What is LOINC?
LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.