72335-3
LaboratoryNPM1 gene c.956dupTCTG transcript/control transcript [# Ratio] in Bone marrow by Molecular genetics method
Definition
The quantification of NPM1 mutation A (c.956dupTCTG) transcripts are compared to a control gene (e.g. ABL1) by real-time PCR (RT-qPCR). NPM1 primers and probes spanning exons 11 and 12 may be used to detect quantify the NPM1 mutation transcripts. Results are based on the normalized copy number [NPM1 mut A copy number/ABL1 copy number) x 100]. This test is based on, but not limited to, IPSOGEN'S NPM1-A MutaQuant Kit, which is used as research tool (as of 2012) for the quantification of NPM1 transcripts in samples previously identified as carrying the NPM1 mutation A. The results are used to monitor the decrease of NPM1 mutA expression.
LOINC 6-Axis Classification
Component
NPM1 gene.c.956dupTCTG transcript/control transcript
Property
NRto
Time Aspect
Pt
System
Bone mar
Scale Type
Qn
Method Type
Molgen
Details
Class
MOLPATH.MUT
Order/Observation
Both
Short Name
NPM1 gene mut A/control Mar
Display Name
NPM1 gene c.956dupTCTG transcript/control transcript Molgen (BM) [# ratio]
Related Names
Frequently Asked Questions
What is LOINC code 72335-3?
LOINC code 72335-3 identifies "NPM1 gene c.956dupTCTG transcript/control transcript [# Ratio] in Bone marrow by Molecular genetics method". The quantification of NPM1 mutation A (c.956dupTCTG) transcripts are compared to a control gene (e.g. ABL1) by real-time PCR (RT-qPCR). NPM1 primers and probes spanning exons 11 and 12 may be used to detect quantify the NPM1 mutation transcripts. Results are based on the normalized copy number [NPM1 mut A copy number/ABL1 copy number) x 100]. This test is based on, but not limited to, IPSOGEN'S NPM1-A MutaQuant Kit, which is used as research tool (as of 2012) for the quantification of NPM1 transcripts in samples previously identified as carrying the NPM1 mutation A. The results are used to monitor the decrease of NPM1 mutA expression.
What does 72335-3 measure?
This code measures NPM1 gene.c.956dupTCTG transcript/control transcript in Bone mar. It belongs to the MOLPATH.MUT class in the LOINC classification.
What is LOINC?
LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.