72334-6
LaboratoryNPM1 gene c.960insCATG transcript/control transcript [# Ratio] in Bone marrow by Molecular genetics method
Definition
The quantification of NPM1 mutation B (c.960insCATG) transcripts are compared to a control gene (e.g. ABL1) by real-time PCR (RT-qPCR). NPM1 primers and probes spanning exons 11 and 12 may be used to detect quantify the NPM1 mutation transcripts. Results are based on the normalized copy number [NPM1 mut B copy number/ABL1 copy number) x 100]. This test is based on, but not limited to, IPSOGEN'S NPM1-B/D MutaQuant Kit, which is used as research tool (as of 2012) for the quantification of NPM1-B transcripts in samples previously identified as carrying the NPM1 mutation B. The results are used to monitor the decrease of NPM1 mutB expression.
LOINC 6-Axis Classification
Component
NPM1 gene.c.960insCATG transcript/control transcript
Property
NRto
Time Aspect
Pt
System
Bone mar
Scale Type
Qn
Method Type
Molgen
Details
Class
MOLPATH.MUT
Order/Observation
Both
Short Name
NPM1 gene mut B/control Mar
Display Name
NPM1 gene c.960insCATG transcript/control transcript Molgen (BM) [# ratio]
Related Names
Frequently Asked Questions
What is LOINC code 72334-6?
LOINC code 72334-6 identifies "NPM1 gene c.960insCATG transcript/control transcript [# Ratio] in Bone marrow by Molecular genetics method". The quantification of NPM1 mutation B (c.960insCATG) transcripts are compared to a control gene (e.g. ABL1) by real-time PCR (RT-qPCR). NPM1 primers and probes spanning exons 11 and 12 may be used to detect quantify the NPM1 mutation transcripts. Results are based on the normalized copy number [NPM1 mut B copy number/ABL1 copy number) x 100]. This test is based on, but not limited to, IPSOGEN'S NPM1-B/D MutaQuant Kit, which is used as research tool (as of 2012) for the quantification of NPM1-B transcripts in samples previously identified as carrying the NPM1 mutation B. The results are used to monitor the decrease of NPM1 mutB expression.
What does 72334-6 measure?
This code measures NPM1 gene.c.960insCATG transcript/control transcript in Bone mar. It belongs to the MOLPATH.MUT class in the LOINC classification.
What is LOINC?
LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.