72313-0
Laboratoryt(4;11)(q21.3;q23)(AFF1,MLL) fusion transcript/control transcript [# Ratio] in Blood or Tissue by Molecular genetics method
Definition
A translocation involving chromosomes 4 and 11, t(4;11)(q21.3;q23), results in a fused transcript between AFF1 and MLL genes. The AFF1-MLL fusion gene is associated with childhood and adult acute lymphoblastic leukemia (ALL) as well as infant acute leukemia. This code is based on, but not limited to, Ispogen's FusionQuant® kit, which uses real-time Quantitative RQ-PCR to quantify the expression level of specific AFF1-MLL fusion transcripts relative to a control gene transcript (e.g. ABL1). Standard curves of known amounts of both the control and fusion transcript are used to calculate the ratio of the fusion transcript signal to the control gene signal.
LOINC 6-Axis Classification
Component
t(4;11)(q21.3;q23)(AFF1,MLL) fusion transcript/control transcript
Property
NRto
Time Aspect
Pt
System
Bld/Tiss
Scale Type
Qn
Method Type
Molgen
Details
Class
MOLPATH.TRNLOC
Order/Observation
Both
Short Name
t(4;11)(AFF1,MLL)/control Bld/T
Display Name
t(4;11)(q21.3;q23)(AFF1,MLL) fusion transcript/control transcript Molgen (Bld/Tiss) [# ratio]
Related Names
Frequently Asked Questions
What is LOINC code 72313-0?
LOINC code 72313-0 identifies "t(4;11)(q21.3;q23)(AFF1,MLL) fusion transcript/control transcript [# Ratio] in Blood or Tissue by Molecular genetics method". A translocation involving chromosomes 4 and 11, t(4;11)(q21.3;q23), results in a fused transcript between AFF1 and MLL genes. The AFF1-MLL fusion gene is associated with childhood and adult acute lymphoblastic leukemia (ALL) as well as infant acute leukemia. This code is based on, but not limited to, Ispogen's FusionQuant® kit, which uses real-time Quantitative RQ-PCR to quantify the expression level of specific AFF1-MLL fusion transcripts relative to a control gene transcript (e.g. ABL1). Standard curves of known amounts of both the control and fusion transcript are used to calculate the ratio of the fusion transcript signal to the control gene signal.
What does 72313-0 measure?
This code measures t(4;11)(q21.3;q23)(AFF1,MLL) fusion transcript/control transcript in Bld/Tiss. It belongs to the MOLPATH.TRNLOC class in the LOINC classification.
What is LOINC?
LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.