72312-2
Laboratoryt(1;19)(q23.3;p13.3)(PBX1,TCF3) fusion transcript/control transcript [# Ratio] in Blood or Tissue by Molecular genetics method
Definition
A translocation involving chromosomes 1 and 19, t(1;19)(q23;p13), results in a fused transcript between TCF3 (formerly E2A) and PBX1 (formerly prl) genes. The TCF3-PBX1 fusion gene is found in approximately 3% of childhood and adult precursor-B acute lymphoblastic leukemia (ALL). This code is based on, but not limited to, Ispogen's E2A-PBX1 FusionQuant® kit, which uses real-time Quantitative RQ-PCR to quantify the expression level of specific TCF3(E2A)-PBX1 fusion gene transcripts relative to a control gene transcript (e.g. ABL1). From the manufacturer's website (2012), "Quantification of E2A-PBX1 fusion gene transcripts has been standardized in the EAC (Europe Against Cancer) program [Gabert J et al. Leukemia. 2003, Beillard E et al. Leukemia. 2003], and IPSOGEN FusionQuant® kits use this validated technology to calibrate and normalize RQ-PCR results."
LOINC 6-Axis Classification
Component
t(1;19)(q23.3;p13.3)(PBX1,TCF3) fusion transcript/control transcript
Property
NRto
Time Aspect
Pt
System
Bld/Tiss
Scale Type
Qn
Method Type
Molgen
Details
Class
MOLPATH.TRNLOC
Order/Observation
Both
Short Name
t(1;19)(PBX1,TCF3)/control Bld/T
Display Name
t(1;19)(q23.3;p13.3)(PBX1,TCF3) fusion transcript/control transcript Molgen (Bld/Tiss) [# ratio]
Related Names
Frequently Asked Questions
What is LOINC code 72312-2?
LOINC code 72312-2 identifies "t(1;19)(q23.3;p13.3)(PBX1,TCF3) fusion transcript/control transcript [# Ratio] in Blood or Tissue by Molecular genetics method". A translocation involving chromosomes 1 and 19, t(1;19)(q23;p13), results in a fused transcript between TCF3 (formerly E2A) and PBX1 (formerly prl) genes. The TCF3-PBX1 fusion gene is found in approximately 3% of childhood and adult precursor-B acute lymphoblastic leukemia (ALL). This code is based on, but not limited to, Ispogen's E2A-PBX1 FusionQuant® kit, which uses real-time Quantitative RQ-PCR to quantify the expression level of specific TCF3(E2A)-PBX1 fusion gene transcripts relative to a control gene transcript (e.g. ABL1). From the manufacturer's website (2012), "Quantification of E2A-PBX1 fusion gene transcripts has been standardized in the EAC (Europe Against Cancer) program [Gabert J et al. Leukemia. 2003, Beillard E et al. Leukemia. 2003], and IPSOGEN FusionQuant® kits use this validated technology to calibrate and normalize RQ-PCR results."
What does 72312-2 measure?
This code measures t(1;19)(q23.3;p13.3)(PBX1,TCF3) fusion transcript/control transcript in Bld/Tiss. It belongs to the MOLPATH.TRNLOC class in the LOINC classification.
What is LOINC?
LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.