72210-8
Laboratoryinv(16)(p13.1;q22.1)(MYH11,CBFB) fusion transcript/control transcript [# Ratio] in Blood or Tissue by Molecular genetics method
Definition
A pericentric inversion of chromosome 16, inv(16)(p13;q22), results in a fused transcript between MYH11 (16p13.1) and CBFB (16q22.1) genes and is known to cause acute myeloid leukemia (AML). Techniques like real-time PCR are used to detect the MYH11-CBFB fused transcript. An endogenous control gene transcript (e.g. ABL1, GUS or BCR) is amplified along with the fusion transcript of interest. Standard curves of known amounts of both the control and fusion transcript are used to calculate the ratio of the fusion transcript signal to the control gene signal.
LOINC 6-Axis Classification
Component
inv(16)(p13.1;q22.1)(MYH11,CBFB) fusion transcript/control transcript
Property
NRto
Time Aspect
Pt
System
Bld/Tiss
Scale Type
Qn
Method Type
Molgen
Details
Class
MOLPATH.INV
Order/Observation
Both
Short Name
inv(16)(p13;q22)/control Bld/T
Display Name
inv(16)(p13.1;q22.1)(MYH11,CBFB) fusion transcript/control transcript Molgen (Bld/Tiss) [# ratio]
Related Names
Frequently Asked Questions
What is LOINC code 72210-8?
LOINC code 72210-8 identifies "inv(16)(p13.1;q22.1)(MYH11,CBFB) fusion transcript/control transcript [# Ratio] in Blood or Tissue by Molecular genetics method". A pericentric inversion of chromosome 16, inv(16)(p13;q22), results in a fused transcript between MYH11 (16p13.1) and CBFB (16q22.1) genes and is known to cause acute myeloid leukemia (AML). Techniques like real-time PCR are used to detect the MYH11-CBFB fused transcript. An endogenous control gene transcript (e.g. ABL1, GUS or BCR) is amplified along with the fusion transcript of interest. Standard curves of known amounts of both the control and fusion transcript are used to calculate the ratio of the fusion transcript signal to the control gene signal.
What does 72210-8 measure?
This code measures inv(16)(p13.1;q22.1)(MYH11,CBFB) fusion transcript/control transcript in Bld/Tiss. It belongs to the MOLPATH.INV class in the LOINC classification.
What is LOINC?
LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.