AutoICD API

72208-2

Laboratory

t(8;21)(q22;q22.3)(RUNX1T1,RUNX1) fusion transcript/control transcript [# Ratio] in Bone marrow by Molecular genetics method

Definition

Translocations between chromosomes 8 and 21, resulting in a fused transcript between RUNXT1 (8q22) and RUNX1 (21q22.3), can be detected with real-time PCR. An endogenous control gene transcript (e.g. ABL1, GUS or BCR) is amplified along with the fusion transcript of interest. Standard curves of known amounts of both the control and fusion transcript are used to calculate the ratio of the fusion transcript signal to the control gene signal.

LOINC 6-Axis Classification

Component

t(8;21)(q22;q22.3)(RUNX1T1,RUNX1) fusion transcript/control transcript

Property

NRto

Time Aspect

Pt

System

Bone mar

Scale Type

Qn

Method Type

Molgen

Details

Class

MOLPATH.TRNLOC

Order/Observation

Both

Short Name

t(8;21)(RUNX1T1,RUNX1)/control Mar

Display Name

t(8;21)(q22;q22.3)(RUNX1T1,RUNX1) fusion transcript/control transcript Molgen (BM) [# ratio]

Related Names

21q22.3ABLABL1ABL1 transcriptAcute myelogenous leukemia 1 translocation 1, cyclin-D relatedAcute myeloid leukemiaAcute myeloid leukemia 1AMLAML1AML1T1L myeloid translocation gene on 8q22BMBONBone marrowCBFA2CBFA2T1CDRcontrol geneCore binding factor runt domain alpha subunit 2DNAETOgene fusiongene translocationGeneticsHeredityHeritableInheritedMARMarrow (bone)MGC2796minimal angle of resolutionMinimum angle of resolutionMolecular geneticsMolecular pathologyMOLPATHMOLPATH.TRANSLOCATIONMTG8Number ratioPCRPoint in timeQNTQuanQuantQuantitativeRandomRNAT primet(8,21)(RUNX1T1,RUNX1) gene translocationt(821)(RUNX1T1,RUNX1)translocationZMYND2

Frequently Asked Questions

What is LOINC code 72208-2?

LOINC code 72208-2 identifies "t(8;21)(q22;q22.3)(RUNX1T1,RUNX1) fusion transcript/control transcript [# Ratio] in Bone marrow by Molecular genetics method". Translocations between chromosomes 8 and 21, resulting in a fused transcript between RUNXT1 (8q22) and RUNX1 (21q22.3), can be detected with real-time PCR. An endogenous control gene transcript (e.g. ABL1, GUS or BCR) is amplified along with the fusion transcript of interest. Standard curves of known amounts of both the control and fusion transcript are used to calculate the ratio of the fusion transcript signal to the control gene signal.

What does 72208-2 measure?

This code measures t(8;21)(q22;q22.3)(RUNX1T1,RUNX1) fusion transcript/control transcript in Bone mar. It belongs to the MOLPATH.TRNLOC class in the LOINC classification.

What is LOINC?

LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.