71805-6
LaboratoryCortisol Free/Cortisone free [Molar ratio] in Urine
Definition
Determining the ratio of urinary-free cortisol to cortisone is useful in evaluating patients with apparent mineralocorticoid excess (AME) syndrome and other forms of adrenal insufficiency. Higher ratios (> 0.5) are observed in patients with AME syndrome and indicate insufficient levels of 11-beta-hydroxy steroid dehydrogenase type 2 (11-beta HSD2), which converts cortisol to cortisone. Lower ratios (<0.15) suggests low activity of the 11-beta-HSD1 enzyme, which converts cortisone to cortisol, and may explain reduced effectiveness of cortisone treatment.
LOINC 6-Axis Classification
Component
Cortisol.free/Cortisone.free
Property
SRto
Time Aspect
Pt
System
Urine
Scale Type
Qn
Method Type
N/A
Details
Class
CHEM
Order/Observation
Both
Short Name
Cortis F/Cortisone Free Ur-sRto
Display Name
Cortisol Free/Cortisone free (U) [Molar ratio]
Related Names
Frequently Asked Questions
What is LOINC code 71805-6?
LOINC code 71805-6 identifies "Cortisol Free/Cortisone free [Molar ratio] in Urine". Determining the ratio of urinary-free cortisol to cortisone is useful in evaluating patients with apparent mineralocorticoid excess (AME) syndrome and other forms of adrenal insufficiency. Higher ratios (> 0.5) are observed in patients with AME syndrome and indicate insufficient levels of 11-beta-hydroxy steroid dehydrogenase type 2 (11-beta HSD2), which converts cortisol to cortisone. Lower ratios (<0.15) suggests low activity of the 11-beta-HSD1 enzyme, which converts cortisone to cortisol, and may explain reduced effectiveness of cortisone treatment.
What does 71805-6 measure?
This code measures Cortisol.free/Cortisone.free in Urine. It belongs to the CHEM class in the LOINC classification.
What is LOINC?
LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.