71356-0
LaboratoryTPMT gene c.238G>C+460G>A+719A>G [Identifier] in Blood or Tissue by Molecular genetics method Narrative
Definition
Three main genetic polymorphisms [c.238G>C (rs1800462), c.460G>A (rs1800460), and c.719A>G (rs16880254)] in the TPMT gene alter metabolization efficiency of the thiopurines in 80-95% of patients. Patients with average TPMT activity are heterozygous for these genetic changes. Patients with deficient enzyme activity are homozygous for these polymorphisms. This code was created for, but not limited to, Asper Biotech's Thiopurine S-Methyltransferase Deficiency - TPMT test.
LOINC 6-Axis Classification
Component
TPMT gene.c.238G>C+460G>A+719A>G
Property
Prid
Time Aspect
Pt
System
Bld/Tiss
Scale Type
Nar
Method Type
Molgen
Details
Class
MOLPATH.PHARMG
Order/Observation
Both
Short Name
TPMT c.238G>C+460G>A+719A>G Bld/T
Display Name
TPMT gene c.238G>C+460G>A+719A>G Molgen Nar (Bld/Tiss)
Related Names
Frequently Asked Questions
What is LOINC code 71356-0?
LOINC code 71356-0 identifies "TPMT gene c.238G>C+460G>A+719A>G [Identifier] in Blood or Tissue by Molecular genetics method Narrative". Three main genetic polymorphisms [c.238G>C (rs1800462), c.460G>A (rs1800460), and c.719A>G (rs16880254)] in the TPMT gene alter metabolization efficiency of the thiopurines in 80-95% of patients. Patients with average TPMT activity are heterozygous for these genetic changes. Patients with deficient enzyme activity are homozygous for these polymorphisms. This code was created for, but not limited to, Asper Biotech's Thiopurine S-Methyltransferase Deficiency - TPMT test.
What does 71356-0 measure?
This code measures TPMT gene.c.238G>C+460G>A+719A>G in Bld/Tiss. It belongs to the MOLPATH.PHARMG class in the LOINC classification.
What is LOINC?
LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.