70666-3

LOINC code 70666-3 identifies "Cold agglutinin [Presence] in Serum by 22 degree C incubation". Cold agglutinins are usually determined at refrigerator temperatures (4 degrees C). In positive cases, surgeons may request testing at additional temperatures, including 18 degrees C, room temperature (22 degrees C), and 28 degrees C, to determine how cold the patient's body temperature can be dropped during surgery. In cardiovascular surgery, the heart is cooled to 25°C to slow down metabolic processes. Since the blood of patients with a history of cold antibodies or cold hemagglutinin disease (such as Raynaud's) is likely to contain cold antibodies, such as anti-M, anti-I and anti-I, testing at various temperatures is performed in order to prevent an acute hemolytic episode.

This code measures Cold agglutinin in Ser. It belongs to the SERO class in the LOINC classification.

LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.