70291-0
Laboratoryinv(16)(p13.1;q22.1)(MYH11,CBFB) fusion transcript [Presence] in Blood or Tissue by Molecular genetics method
Definition
This term is used to identify a leukemia causing inversion on chromosome 16 resulting in gene fusion between CBFB (16q22) and MYH11 (16p13) genes. The term was created for (but not limited to) DNA Technology's HemaVision HV01-28N kit, a qualitative in vitro diagnostic test for 28 leukemia causing chromosomal alterations including more than 80 breakpoints plus associated mRNA splice variants. Reverse transcription followed by multiplex nested polymerase chain reactions (RT-PCR) and agarose gel electrophoresis are used to identify gene fusions caused by chromosomal translocations, gene deletions or inversions. Testing information is useful for predicting development of the disease and selection of treatment.
LOINC 6-Axis Classification
Component
inv(16)(p13.1;q22.1)(MYH11,CBFB) fusion transcript
Property
Arb
Time Aspect
Pt
System
Bld/Tiss
Scale Type
Ord
Method Type
Molgen
Details
Class
MOLPATH.INV
Order/Observation
Both
Short Name
inv(16)(p13;q22) Bld/T Ql
Display Name
inv(16)(p13.1;q22.1)(MYH11,CBFB) fusion transcript Molgen Ql (Bld/Tiss)
Related Names
Frequently Asked Questions
What is LOINC code 70291-0?
LOINC code 70291-0 identifies "inv(16)(p13.1;q22.1)(MYH11,CBFB) fusion transcript [Presence] in Blood or Tissue by Molecular genetics method". This term is used to identify a leukemia causing inversion on chromosome 16 resulting in gene fusion between CBFB (16q22) and MYH11 (16p13) genes. The term was created for (but not limited to) DNA Technology's HemaVision HV01-28N kit, a qualitative in vitro diagnostic test for 28 leukemia causing chromosomal alterations including more than 80 breakpoints plus associated mRNA splice variants. Reverse transcription followed by multiplex nested polymerase chain reactions (RT-PCR) and agarose gel electrophoresis are used to identify gene fusions caused by chromosomal translocations, gene deletions or inversions. Testing information is useful for predicting development of the disease and selection of treatment.
What does 70291-0 measure?
This code measures inv(16)(p13.1;q22.1)(MYH11,CBFB) fusion transcript in Bld/Tiss. It belongs to the MOLPATH.INV class in the LOINC classification.
What is LOINC?
LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.