AutoICD API

69002-4

Laboratory

Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

Definition

This term was created for (but not limited to) Gen-Probe's Aptima HPV assay (Cat No. 302610) that detects the E6 and E7 polycistronic mRNA from 14 high-risk HPV genotypes (16,18,31,33,35,39,45,51,52,56,58,59,66,and 68) that can lead to cervical cancer. E6/E7 genes in high-risk HPV genotypes are known as oncogenes because of their continuous expression, which leads to disruption of cell-cycle check points and cell genome instability through alteration of cellular p53 and retinoblastoma protein functions. This test is similar to LOINC 69358-0, which measures cells containing E6+E7 mRNA via flow cytometry.

LOINC 6-Axis Classification

Component

Human papilloma virus 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 mRNA

Property

PrThr

Time Aspect

Pt

System

Cvx

Scale Type

Ord

Method Type

Probe.amp.tar

Details

Class

MICRO

Order/Observation

Both

Short Name

HPV E6+E7 mRNA Cvx Ql NAA+probe

Display Name

HPV E6+E7 mRNA NAA+probe Ql (Cvx)

Related Names

3 Self-Sustaining Sequence Replication3SR SRAmplifAmplificationAmplifiedCervixDNA NUCLEIC ACID PROBEDNA probeGenital tractGenital wartsGynGynecologyHPVHPV E6+E7HPV E6+E7 mRNAHPV I/H Risk 4HPV16HPV16 and 18HPV16+18HPV16+18+H Risk 12Human papillomavirusIDInfectious DiseaseInfectiousDiseaseLATLCRLigase chain reactionLigation-activated transcriptionMicrobiologyNAA+probeNAATNASBANucleic acid sequence based analysisOBObGynObstetricsOrdinalPapilloma virus high riskPCRPoint in timePolymerase chain reactionPRProbe ampProbe with ampificationProbe with target amplificationQBRQLQualQualitativeRandomScreenSDAStrand Displacement AmplificationTMATranscription mediated amplification

Frequently Asked Questions

What is LOINC code 69002-4?

LOINC code 69002-4 identifies "Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection". This term was created for (but not limited to) Gen-Probe's Aptima HPV assay (Cat No. 302610) that detects the E6 and E7 polycistronic mRNA from 14 high-risk HPV genotypes (16,18,31,33,35,39,45,51,52,56,58,59,66,and 68) that can lead to cervical cancer. E6/E7 genes in high-risk HPV genotypes are known as oncogenes because of their continuous expression, which leads to disruption of cell-cycle check points and cell genome instability through alteration of cellular p53 and retinoblastoma protein functions. This test is similar to LOINC 69358-0, which measures cells containing E6+E7 mRNA via flow cytometry.

What does 69002-4 measure?

This code measures Human papilloma virus 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 mRNA in Cvx. It belongs to the MICRO class in the LOINC classification.

What is LOINC?

LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.