68466-2
LaboratoryEpstein-Barr virus-encoded RNA 1 [Presence] in Tissue by Probe
Definition
This term is used for the detection of nuclear Epstein-Barr virus-encoded RNA 1 (EBER1) by in situ hybridization on tissue. Presence of EBER1 indicates a latent EBV infection. EBV encodes two small nuclear RNAs, EBER1 and EBER2, which are the most abundant viral transcripts in latently infected cells. They are non-polyadenylated and thus not translated into protein. Their function is to inhibit interferon-mediated antiviral effects and apoptosis. Since they are expressed at high levels (around a million copies per latently infected cell), they are considered to be an ideal marker of latent EBV infection. In situ hybridization targeting one or both EBERs is used to determine whether a biopsied tumor is EBV-related.
LOINC 6-Axis Classification
Component
Epstein-Barr virus-encoded RNA 1
Property
PrThr
Time Aspect
Pt
System
Tiss
Scale Type
Ord
Method Type
Probe
Details
Class
MICRO
Order/Observation
Both
Short Name
EBV-encoded RNA1 Tiss Ql Probe
Display Name
EBV-encoded RNA 1 Probe Ql (Tiss)
Related Names
Frequently Asked Questions
What is LOINC code 68466-2?
LOINC code 68466-2 identifies "Epstein-Barr virus-encoded RNA 1 [Presence] in Tissue by Probe". This term is used for the detection of nuclear Epstein-Barr virus-encoded RNA 1 (EBER1) by in situ hybridization on tissue. Presence of EBER1 indicates a latent EBV infection. EBV encodes two small nuclear RNAs, EBER1 and EBER2, which are the most abundant viral transcripts in latently infected cells. They are non-polyadenylated and thus not translated into protein. Their function is to inhibit interferon-mediated antiviral effects and apoptosis. Since they are expressed at high levels (around a million copies per latently infected cell), they are considered to be an ideal marker of latent EBV infection. In situ hybridization targeting one or both EBERs is used to determine whether a biopsied tumor is EBV-related.
What does 68466-2 measure?
This code measures Epstein-Barr virus-encoded RNA 1 in Tiss. It belongs to the MICRO class in the LOINC classification.
What is LOINC?
LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.