66882-2

LOINC code 66882-2 identifies "Skin IgG Ab [Presence] in Serum by Guinea pig esophagus substrate". The detection of skin antibodies assists in the diagnosis of chronic vesicular-bullous diseases such as pemphigus and pemphigoid. When patient sera are incubated on monkey or guinea pig esophagus sections, anti-skin antibodies present in the serum will bind with disease-specific patterns by immunofluorescence. For example, the intercellular (IC) antibody pattern diagnoses pemphigus with a 90% sensitivity. Testing with the 2 different species of esophagus sections (monkey and guinea pig) assists in distinguishing different forms of pemphigus. Antibodies following a basement membrane pattern are present in bullous pemphigoid (70%), vesicular pemphigoid (50%) and cicatricial pemphigoid (10%).

This code measures Skin Ab.IgG in Ser. It belongs to the SERO class in the LOINC classification.

LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.