62320-7
LaboratoryT-cell receptor excision circle [#/volume] in DBS by NAA with probe detection
Definition
In newborn screening laboratories where dried blood spots (DBS) are the only available specimens, the test for T cell receptor excision circles (TREC) has been established as a reliable method in population-based pilot studies. TRECs are circular episomal DNA generated at the rearrangement of T cell antigen-receptor gene segments during maturation of T lymphocytes in the thymus. They are non-replicating byproducts that stay in the recent thymic emigrants in the peripheral blood. As such, they can serve as sensitive markers of T cell production in the newborn infant.
LOINC 6-Axis Classification
Component
T-cell receptor excision circle
Property
NCnc
Time Aspect
Pt
System
Bld.dot
Scale Type
Qn
Method Type
Probe.amp.tar
Details
Class
CHEM
Order/Observation
Both
Short Name
TREC # DBS NAA+probe
Display Name
T-cell receptor excision circle NAA+probe (DBS) [#/Vol]
Related Names
Frequently Asked Questions
What is LOINC code 62320-7?
LOINC code 62320-7 identifies "T-cell receptor excision circle [#/volume] in DBS by NAA with probe detection". In newborn screening laboratories where dried blood spots (DBS) are the only available specimens, the test for T cell receptor excision circles (TREC) has been established as a reliable method in population-based pilot studies. TRECs are circular episomal DNA generated at the rearrangement of T cell antigen-receptor gene segments during maturation of T lymphocytes in the thymus. They are non-replicating byproducts that stay in the recent thymic emigrants in the peripheral blood. As such, they can serve as sensitive markers of T cell production in the newborn infant.
What does 62320-7 measure?
This code measures T-cell receptor excision circle in Bld.dot. It belongs to the CHEM class in the LOINC classification.
What is LOINC?
LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.