53769-6
LaboratoryCD55+CD59 deficient RBC actual/normal in Blood
Definition
Glycophosphatidylinositol(GPI)-linked membrane proteins CD55 (DAF-Decay Acclerating Factor) and CD59 (Membrane Inhibitor of Reactive Lysis-MIRL) are normally present on red blood cells to protect the cells from destruction by complement in the immune system. The expression of CD55 and CD59 is deficient in a subpopulation of patients with paroxysmal nocturnal hemoglobinuria(PNH). PNH is a disorder is which the stem cells lack proteins tht prevent them from being destroyed by the body, resulting in intermittant destruction of cells, usually at night. PNH is characterized by chronic intravascular hemolysis, bone marrow failure and life threatening thrombosis. Information from ARUP Laboratories and www.pnhfoundation.org, accessed 2008 01 18.
LOINC 6-Axis Classification
Component
Erythrocytes.CD55+CD59 deficient actual/normal
Property
RelRto
Time Aspect
Pt
System
Bld
Scale Type
Qn
Method Type
N/A
Details
Class
CELLMARK
Order/Observation
Observation
Short Name
CD55+CD59 def RBC Act/Nor Bld
Display Name
CD55+CD59 deficient RBC actual/normal (Bld) [Relative ratio]
Related Names
Frequently Asked Questions
What is LOINC code 53769-6?
LOINC code 53769-6 identifies "CD55+CD59 deficient RBC actual/normal in Blood". Glycophosphatidylinositol(GPI)-linked membrane proteins CD55 (DAF-Decay Acclerating Factor) and CD59 (Membrane Inhibitor of Reactive Lysis-MIRL) are normally present on red blood cells to protect the cells from destruction by complement in the immune system. The expression of CD55 and CD59 is deficient in a subpopulation of patients with paroxysmal nocturnal hemoglobinuria(PNH). PNH is a disorder is which the stem cells lack proteins tht prevent them from being destroyed by the body, resulting in intermittant destruction of cells, usually at night. PNH is characterized by chronic intravascular hemolysis, bone marrow failure and life threatening thrombosis. Information from ARUP Laboratories and www.pnhfoundation.org, accessed 2008 01 18.
What does 53769-6 measure?
This code measures Erythrocytes.CD55+CD59 deficient actual/normal in Bld. It belongs to the CELLMARK class in the LOINC classification.
What is LOINC?
LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.