53767-0

LOINC code 53767-0 identifies "HLA-A+B+C SBT [Interpretation] by High resolution". HLA-ABC sequence based typing results in HLA allele assignment for each HLA locus(A,B,C). HLA antigens are the major histocompatibility antigens. HLA Class 1 Sequence-Based typing (HLA-SBT) is used to identify HLA allelic polymorphisms at the level of individual nucleotides using genomic DNA amplified by polymerase chain reaction(PCR). If fewer than two alleles are reported for a locus, the patient can most likely be considered homozygous for that locus, but there is a possibility of an undetected rare allele. HLA-SBT should be used in addition to HLA Class 1 serology and/or low to intermediate resolution molecular typing using either SSP(sequence-specific primers) or SSOPH(sequence-specific oligonucleotide blot hydridization) technology. For clinical purposes, this test should be used as a reflex test to identify unrelated bone marrow donors who are HLA A,B, and C genotypic matches with the intended recipient.

This code measures HLA-A+B+C SBT in Bld/Tiss. It belongs to the HLA class in the LOINC classification.

LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.