53758-9

LOINC code 53758-9 identifies "HLA-DRB1 SBT [Type] in Specimen by High resolution". HLA-DRB typing identifies HLA allelic polymorphism using DNA amplified by Polymerase Chain Reaction(PCR). HLA typing is vital for bone marrow transplantation. Well-matched donors increase patient survival and decreases incidence of graft vs.host disease. HLA-DRB1 sequence typing is used to identify unrelated allogeneic bone marrow donors who are HLA-DRB genotypic matches to the recipient. For DRB1, the allelic variability is mainly in the second exon, clustered in three distinct regions that show variance. If fewer than two alleles is reported for a locus, the patient is likely to be homozygous for that locus, but the possibility of the presence of rare alleles exists. Information from ARUP Laboratories 2007 07 17.

This code measures HLA-DRB1 SBT in XXX. It belongs to the HLA class in the LOINC classification.

LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.