53714-2
LaboratoryGlial nuclear type 1 Ab [Titer] in Cerebral spinal fluid
Definition
Glial Nuclear Antibody Antibody (AGNA) Type 1 Cerebrospinal Fluid (CSF) Titer. This antibody is a marker found in paraneoplastic syndrome associated with small cell lung carcinoma (SCLC). It is also closely associated with paraneoplastic Lambert-Easton Myasthenia Syndrome (LEMS). There appears to be a tight association between AGNA and voltage-gated calcium channel antibodies in patients with SCLC. Patients with AGNA have characteristic nuclear staining of the Bergmann glia in the Purkinje cell layer of the cerebellum. Information from "Paraneoplastic Limbic encephalitis associated with potassium channel antibodies: value of anti-glial nuclear antibodies in identifying the tumour" by L. Zuliani, A. Saiz, B. Tavolato, B. Giometto, A. Vincent and Francesc Graus, JNNP m 2007; 78; p. 204-205.
LOINC 6-Axis Classification
Component
Glial nuclear type 1 Ab
Property
Titr
Time Aspect
Pt
System
CSF
Scale Type
SemiQn
Method Type
N/A
Details
Class
SERO
Order/Observation
Both
Short Name
Glial nuc type 1 Ab Titr CSF
Display Name
Glial nuclear type 1 Ab (CSF) [Titer]
Related Names
Frequently Asked Questions
What is LOINC code 53714-2?
LOINC code 53714-2 identifies "Glial nuclear type 1 Ab [Titer] in Cerebral spinal fluid". Glial Nuclear Antibody Antibody (AGNA) Type 1 Cerebrospinal Fluid (CSF) Titer. This antibody is a marker found in paraneoplastic syndrome associated with small cell lung carcinoma (SCLC). It is also closely associated with paraneoplastic Lambert-Easton Myasthenia Syndrome (LEMS). There appears to be a tight association between AGNA and voltage-gated calcium channel antibodies in patients with SCLC. Patients with AGNA have characteristic nuclear staining of the Bergmann glia in the Purkinje cell layer of the cerebellum. Information from "Paraneoplastic Limbic encephalitis associated with potassium channel antibodies: value of anti-glial nuclear antibodies in identifying the tumour" by L. Zuliani, A. Saiz, B. Tavolato, B. Giometto, A. Vincent and Francesc Graus, JNNP m 2007; 78; p. 204-205.
What does 53714-2 measure?
This code measures Glial nuclear type 1 Ab in CSF. It belongs to the SERO class in the LOINC classification.
What is LOINC?
LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.