53712-6
LaboratoryNeuronal nuclear type 2 Ab [Titer] in Cerebral spinal fluid
Definition
Antineuronal Nuclear Antibody (ANNA) Type 2 Cerebrospinal Fluid (CSF) Titer. This antibody recognizes a set of protein antigens of 55 and 80 kD found in neuronal cell nuclei. Patients usually present with signs of midbrain, brain stem, cerebellar and/or spinal cord dysfunction. Ocular opsoclonus-myoclonus may be a symptom. Para neoplastic opsoclonus, which is characterized by involuntary rapid movement of the eyes in both vertical and horizontal planes, is most often associated with breast cancer and SCLC (small lung cell carcinoma). The autoantibody has also been detected in patients with bladder and cervical cancer. Paraneoplastic syndromes are autoantibody-mediated neurologic disorders associated with underlying tumors. These syndromes arise when systemic tumors express antigens normally found only in neural tissues. Information from http://www.clinlabnavigator.com accessed 2008 14 02.
LOINC 6-Axis Classification
Component
Neuronal nuclear type 2 Ab
Property
Titr
Time Aspect
Pt
System
CSF
Scale Type
SemiQn
Method Type
N/A
Details
Class
SERO
Order/Observation
Both
Short Name
Hu2 Ab Titr CSF
Display Name
Neuronal nuclear type 2 Ab (CSF) [Titer]
Related Names
Frequently Asked Questions
What is LOINC code 53712-6?
LOINC code 53712-6 identifies "Neuronal nuclear type 2 Ab [Titer] in Cerebral spinal fluid". Antineuronal Nuclear Antibody (ANNA) Type 2 Cerebrospinal Fluid (CSF) Titer. This antibody recognizes a set of protein antigens of 55 and 80 kD found in neuronal cell nuclei. Patients usually present with signs of midbrain, brain stem, cerebellar and/or spinal cord dysfunction. Ocular opsoclonus-myoclonus may be a symptom. Para neoplastic opsoclonus, which is characterized by involuntary rapid movement of the eyes in both vertical and horizontal planes, is most often associated with breast cancer and SCLC (small lung cell carcinoma). The autoantibody has also been detected in patients with bladder and cervical cancer. Paraneoplastic syndromes are autoantibody-mediated neurologic disorders associated with underlying tumors. These syndromes arise when systemic tumors express antigens normally found only in neural tissues. Information from http://www.clinlabnavigator.com accessed 2008 14 02.
What does 53712-6 measure?
This code measures Neuronal nuclear type 2 Ab in CSF. It belongs to the SERO class in the LOINC classification.
What is LOINC?
LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.