53711-8

LOINC code 53711-8 identifies "Neuronal nuclear type 1 Ab [Titer] in Cerebral spinal fluid". Anti-Neuronal Nuclear Antibody Type 1 Cerebrospinal fluid (CSF) titer. This antibody recognizes a 35-40 kD component found in neuronal cell nuclei. ANNA-1 antibody is found almost exclusively in patients with a history of tobacco use or passive exposure. Women are affected twice as often as men. Cancer has been found in more than 90% of seropositive patients. Small cell lung carcinoma (SCLC) has been found in 80% of patients. A second malignant neoplasm is found in 13% of patients positive for ANNA-1 who have SCLC. The most common clinical presentation of patients positive for ANNA-1 is peripheral neuropathy, but they can exhibit any element of encephalomyeloradiculopathy. About 10% of patients present with gastroparesis or intestinal obstruction. ANNA-1 has also been detected in children with intestinal dysmotility, cerbellar ataxia, and brainstem encephalitis with and without neuroblastoma. It is detected in 5 to 10% of patients with SCLC who do not have a paraneoplastic syndrome. Paraneoplastic syndromes are autoantibody-mediated neurologic disorders associated with underlying tumors. These syndromes arise when systemic tumors express antigens normally found only in neural tissue. Serum is the preferred specimen. CSF results are sometimes positive when serum results are negative. If a lumbar puncture is going to be performed as part of the diagnostic workup, CSF testing is recommended to improve the detection rate. Information from http://www.clinlabnavigator.com accessed 2008 15 02.

This code measures Neuronal nuclear type 1 Ab in CSF. It belongs to the SERO class in the LOINC classification.

LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.