53708-4

LOINC code 53708-4 identifies "Glutamate decarboxylase 65 Ab [Moles/volume] in Cerebral spinal fluid". Glutamic acid decarboxylase (GAD65) is an enzyme that is produced primarily by pancreatic islet cells. Glutamic Acid Decarboxylase antibodies are present in the majority of individuals with new-onset diabetes and in individuals in the prediabetic phase of the disease. It appears early in the disease process prior to clinical symptoms and can be used to predict who will develop IDDM (insulin-dependent diabetes mellitus). Measurement of GAD65 antibody can be of use in distinguishing insulin-dependent from non-insulin dependent diabetics when the clinical history is ambiguous. GAD65 autoantibodies are often markedly elevated in patients with the stiff-person syndrome (also known as stiff-man syndrome), a condition that is associated with fluctuating stiffness and paroxysmal spasms of the trunk and legs. Information from http:www.labcorp.com (Laboratory Corporation of America), accessed 2008 02 13.

This code measures Glutamate decarboxylase 65 Ab in CSF. It belongs to the SERO class in the LOINC classification.

LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.