AutoICD API

49683-6

Laboratory

ERBB2 gene copy number/Chromosome 17 copy number in Tissue by FISH

Definition

The ratio of HER-2/neu (ERBB2 gene) to CEP17 probes by in situ hybridization assays (e.g. FISH) to determine overexpression of HER-2/neu protein in breast cancer. CEP17 is used as an internal control and to account for aneusomy (varying number) of chromosome 17. A ratio of >2.0 indicates gene amplification and overexpression of HER-2/neu according to the 2013 ASCO-CAP HER2 test guideline recommendations. Results are used to assist in dose selection for certain drugs, assess eligibility for trastuzumab (Herceptin®) treatment, predict response to drug therapies and overall survival in patients with breast cancer. For testing without an internal control probe, see LOINCs 31150-6 and 48675-3. For determining HER-2 status by Immunohistochemistry (IHC), see LOINC 18474-7.

LOINC 6-Axis Classification

Component

ERBB2 gene copy number/Chromosome 17 copy number

Property

NRto

Time Aspect

Pt

System

Tiss

Scale Type

Qn

Method Type

FISH

Details

Class

MOLPATH

Order/Observation

Both

Short Name

ERBB2 copy num/Chr 17 copy num Tiss FISH

Display Name

ERBB2 copy number/Chromosome 17 copy number FISH (Tiss) [# ratio]

Related Names

breast cancerCD340CEP17c-erb B2Chr 17 copy numChromosomChromosome 17 centromereChromosome Enumeration Probe 17ChromosomesErbB-2ERBB2 copy numerb-b2 receptor tyrosine kinase 2Fluorescent in situ hybridizationGeneticsHER2HER-2HER2/neuHER-2/neuHeredityHeritableInheritedMLN 19Molecular pathologyMOLPATHNEUNGLNoNumNumber ratioOncologyp185Point in timeQNTQuanQuantQuantitativeRandomTissueTissue, unspecifiedTKR1v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)

Frequently Asked Questions

What is LOINC code 49683-6?

LOINC code 49683-6 identifies "ERBB2 gene copy number/Chromosome 17 copy number in Tissue by FISH". The ratio of HER-2/neu (ERBB2 gene) to CEP17 probes by in situ hybridization assays (e.g. FISH) to determine overexpression of HER-2/neu protein in breast cancer. CEP17 is used as an internal control and to account for aneusomy (varying number) of chromosome 17. A ratio of >2.0 indicates gene amplification and overexpression of HER-2/neu according to the 2013 ASCO-CAP HER2 test guideline recommendations. Results are used to assist in dose selection for certain drugs, assess eligibility for trastuzumab (Herceptin®) treatment, predict response to drug therapies and overall survival in patients with breast cancer. For testing without an internal control probe, see LOINCs 31150-6 and 48675-3. For determining HER-2 status by Immunohistochemistry (IHC), see LOINC 18474-7.

What does 49683-6 measure?

This code measures ERBB2 gene copy number/Chromosome 17 copy number in Tiss. It belongs to the MOLPATH class in the LOINC classification.

What is LOINC?

LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.